EFFECT OF IT KETOROLAC FOLLOWING ACUTE OPIOID EXPOSURE

急性阿片类药物暴露后酮咯酸的影响

• 批准号: 8167027
• 负责人: James Eisenach
• 金额: $ 1.67万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167027
• 关键词: Acute; Area; Capsaicin; Computer Retrieval of Information on Scientific Projects Database; Dinoprostone; Funding; Grant; Heating; Hyperalgesia; Hypersensitivity; Infusion procedures; Institution; Ketorolac; Mechanics; Opioid; Outcome Measure; Randomized; Research; Research Personnel; Resources; Saline; Source; Spinal; United States National Institutes of Health; allodynia; healthy volunteer; primary outcome; remifentanil; secondary outcome

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis: IV remifentanil stimulates spinal COX activity, leading to increased CSF PGE2 concentrations and areas of capsaicin-induced mechanical hypersensitivity after remifentanil infusion, and these effects will be blocked by intrathecal ketorolac Synopsis: Areas of mechanical hyperalgesia and allodynia will be established by topical capsaicin + intermittent heat in healthy volunteers, who will be randomized to receive intrathecal saline or ketorolac during remifentanil infusion, with primary outcome measure area of hyperalgesia and secondary outcome measure CSF PGE2 concentration after stopping remifentanil.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 假设：静脉注射瑞典刺激脊柱COX活性，导致CSF PGE2浓度和辣椒素输注后辣椒素诱导的机械性超敏反应的面积增加，这些作用将被鞘内的酮洛拉克斯阻止 概要：在健康志愿者中，局部辣椒蛋白 +间歇性热将建立机械性超痛性和异常性疾病的区域，他们将在雷米富尼氏菌输液期间随机接收鞘内盐水或酮洛拉克，并具有高速度的主要结果测量面积，并在高温和第二次pge2 pege2 persifation soperage soperagennal soperann persiftation soperagenanial soperagenanial。