EFFECT OF IT KETOROLAC FOLLOWING ACUTE OPIOID EXPOSURE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 假设：静脉注射瑞芬太尼刺激脊髓环氧合酶活性，导致注射瑞芬太尼后脑脊液前列腺素E_2浓度增加和辣椒素诱导的机械过敏区域增加，这些作用将被鞘内酮咯酸阻断。 内容提要：在健康志愿者中，局部应用辣椒素+间歇加热将建立机械性痛觉过敏和痛觉过敏的区域，他们将在瑞芬太尼输注期间随机接受鞘内注射生理盐水或酮咯酸，主要结果测量痛觉过敏区域，次要结果测量停止瑞芬太尼后脑脊液前列腺素E_2浓度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis: IV remifentanil stimulates spinal COX activity, leading to increased CSF PGE2 concentrations and areas of capsaicin-induced mechanical hypersensitivity after remifentanil infusion, and these effects will be blocked by intrathecal ketorolac Synopsis: Areas of mechanical hyperalgesia and allodynia will be established by topical capsaicin + intermittent heat in healthy volunteers, who will be randomized to receive intrathecal saline or ketorolac during remifentanil infusion, with primary outcome measure area of hyperalgesia and secondary outcome measure CSF PGE2 concentration after stopping remifentanil.