EFFECT OF IT KETOROLAC FOLLOWING ACUTE OPIOID EXPOSURE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 假设：静脉注射瑞芬太尼刺激脊髓考克斯活性，导致瑞芬太尼输注后CSF PGE 2浓度和辣椒素诱导的机械超敏反应面积增加，鞘内注射酮咯酸可阻断这些作用 简介：将通过局部辣椒素+间歇性加热在健康志愿者中建立机械性痛觉过敏和异常性疼痛的区域，这些志愿者将在瑞芬太尼输注期间随机接受鞘内盐水或酮咯酸，主要结局测量痛觉过敏的区域，次要结局测量停用瑞芬太尼后的CSF PGE 2浓度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis: IV remifentanil stimulates spinal COX activity, leading to increased CSF PGE2 concentrations and areas of capsaicin-induced mechanical hypersensitivity after remifentanil infusion, and these effects will be blocked by intrathecal ketorolac Synopsis: Areas of mechanical hyperalgesia and allodynia will be established by topical capsaicin + intermittent heat in healthy volunteers, who will be randomized to receive intrathecal saline or ketorolac during remifentanil infusion, with primary outcome measure area of hyperalgesia and secondary outcome measure CSF PGE2 concentration after stopping remifentanil.