CLONIDINE-INDUCED SPRINAL ACETYLCHOLINE RESEARCH

可乐定诱导的螺旋乙酰胆碱研究

• 批准号: 7607684
• 负责人: James Eisenach
• 金额: $ 0.13万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607684
• 关键词: Acetylcholine; Adverse effects; Analgesics; Brain; Cerebrospinal Fluid; Chronic; Clonidine; Computer Retrieval of Information on Scientific Projects Database; Dose; Funding; Grant; Individual; Injury; Institution; Medicine; Nerve Fibers; Nerve Pain; Neuropathy; Operative Surgical Procedures; Pain; Pain Clinics; Pharmaceutical Preparations; Protocols documentation; Research; Research Personnel; Resources; Source; Thinking; United States National Institutes of Health; Work; chronic neuropathic pain; chronic pain; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol is part of a Pain Center Grant that focuses on how pain itself, especially chronic neuropathic pain, alters the response to traditional and non-traditional analgesics. The way that nerve fibers carry the information of pain to the brain is thought to change after surgery and in chronic pain. For this reason, some medicines work better to relieve pain in healthy people who have a sudden painful injury compared to those after surgery or those with chronic pain. Currently available pain medications may not relieve all types of pain or may relieve pain only at doses that produce side effects and potential complications. The aim of this protocol is to understand the mechanisms by which intrathecal clonidine increases in potency and efficacy by looking at the cerebrospinal fluid of healthy individuals before and after clonidine administration as well as looking at the spinal fluid of people that have chronic neuropathic nerve pain.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该方案是疼痛中心赠款的一部分，重点是疼痛本身，特别是慢性神经性疼痛，如何改变对传统和非传统镇痛药的反应。神经纤维将疼痛信息传递到大脑的方式被认为在手术后和慢性疼痛中会发生变化。 出于这个原因，与手术后或慢性疼痛患者相比，一些药物更好地缓解突然疼痛损伤的健康人的疼痛。目前可用的止痛药可能无法缓解所有类型的疼痛，或者只能在产生副作用和潜在并发症的剂量下缓解疼痛。 本方案的目的是通过观察可乐定给药前后健康个体的脑脊液以及观察患有慢性神经性神经痛的人的脊髓液来了解鞘内可乐定增加效力和疗效的机制。