OPEN STUDY OF CHRONIC ADMINISTRATION OF CILOSTAZOL

长期服用西洛他唑的公开研究

• 批准号: 3744957
• 负责人: JOHN ROBIN CROUSE
• 金额: --
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3744957
• 关键词: artery occlusion; atherosclerosis; cardiovascular disorder chemotherapy; drug screening /evaluation; exercise; human subject; human therapy evaluation; muscle metabolism; pain; platelet aggregation inhibitors; vasodilators

Patients with chronic occlusive arterial disease due to atherosclerosis are often asymptomatic at rest but experience pain during exercise. Intermittent claudication indicates skeletal muscle blood flow insufficient to meet increases in metabolic demand. Cilostazol is a potent inhibitor of platelet aggregation which also possesses some vasodilating properties. This trial seeks to assess the safety and efficacy of chronic administration of cilostazol in these patients.

动脉粥样硬化所致慢性闭塞性动脉疾病患者 通常在休息时没有症状，但在运动时会感到疼痛。 间歇性跛行表明骨骼肌血流 不足以满足代谢需求的增加。 西洛他唑是一种 有效的血小板聚集抑制剂，也具有一些 血管舒张特性。 该试验旨在评估安全性， 这些患者长期服用西洛他唑的疗效。