METABOLIC STUDIES IN HUMAN ATHEROSCLEROSIS

人类动脉粥样硬化的代谢研究

• 批准号: 3852891
• 负责人: JOHN ROBIN CROUSE
• 金额: --
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3852891
• 关键词: adipose tissue; angiography; atherosclerosis; blood lipoprotein metabolism; coronary disorder; disease /disorder proneness /risk; eating; fats; female; human subject; hyperlipidemia; lipid metabolism; magnetic resonance imaging; male; noninvasive diagnosis; nutrition related tag

This project will evaluate the strength of association of alimentary lipemia, after adjustment for traditional and nontraditional risk factors, with obstructive coronary artery disease (CAD), extent of extracranial carotid atherosclerosis (ECA), and progression rates of ECA in men and women whose coronary status is defined at angiography. Women will be oversampled relative to men so that final accrual rates will be similar for both. In particular, new risk factors we will control for include the relation of intraabdominal fat (noninvasively imaged by a new MRI technique), Lp(a) level and isoforms, factors related to thrombosis and thrombolysis, and lipoprotein subfractions (HDL, LDL), and traditional risk factors. We will use multivariate analysis to investigate the independent strength of association of postprandial lipemia to outcome and to assess the possible role of certain factors (e.g. HDL, adipose distribution) as intermediaries in its effects. This work builds on our ongoing research experience in patients with CAD, on our considerable experience with non- invasive imaging of the carotid arteries, on newly developed methodology for imaging intraabdominal fat, on evidence that fat pattern relates to obstructive CAD (recently accepted for publication), and on the considerable expertise with lipids and lipoproteins at this institution. Availability of the General Clinical Research Center will afford us he opportunity, for the first time, to relate metabolic parameters to atherosclerosis.

该项目将评估食品协会的实力 调整传统和非传统危险因素后的脂血症， 患有阻塞性冠状动脉疾病（CAD），颅外范围 颈动脉粥样硬化 (ECA) 以及男性和女性中 ECA 的进展率 通过血管造影确定冠状动脉状况的女性。 女性将会 相对于男性进行过度抽样，因此最终的应计率将与男性相似 两个都。 特别是，我们将控制的新风险因素包括 腹内脂肪的关系（通过新的 MRI 无创成像 技术）、Lp（a）水平和异构体、与血栓形成相关的因素和 溶栓、脂蛋白亚组分（HDL、LDL）以及传统风险 因素。 我们将使用多变量分析来研究独立的 餐后血脂与结果的关联强度和评估 某些因素（例如 HDL、脂肪分布）的可能作用 中介的作用。 这项工作建立在我们正在进行的研究的基础上 CAD 患者的经验，以及我们在治疗非 CAD 患者方面的丰富经验 采用新开发的方法对颈动脉进行侵入性成像 用于腹内脂肪成像，有证据表明脂肪模式与 阻塞性 CAD（最近接受出版），以及 该机构在脂质和脂蛋白方面拥有丰富的专业知识。 普通临床研究中心的可用性将为我们提供他 第一次有机会将代谢参数与 动脉粥样硬化。