MULTI DOSE STUDY OF CILOSTAZOL

西洛他唑的多剂量研究

• 批准号: 3767250
• 负责人: JOHN ROBIN CROUSE
• 金额: --
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3767250
• 关键词: blood vessel occlusion; cardiovascular disorder chemotherapy; clinical trials; dosage; drug screening /evaluation; exercise; human subject; human therapy evaluation; ischemia; pain; platelet aggregation inhibitors; quinoline analog; vasodilators

Chronic occlusive vascular disease produces exercise-induced pain when skeletal muscle blood flow is insufficient and ischemia occurs. Cilostazol has active vasodilative properties and is a platelet aggregation inhibitor. This study will assess the safety and efficacy of different dosages of cilostazol versus placebo in individuals with this diagnosis. Performance measures on standardized treadmill testing will document changes in initial and absolute claudication distances.

慢性闭塞性血管疾病产生运动引起的疼痛， 骨骼肌血流量不足并发生局部缺血。 西洛他唑具有积极的血管扩张特性， 聚集抑制剂本研究将评估以下药物的安全性和疗效： 不同剂量的西洛他唑与安慰剂的个体， 诊断. 标准化跑步机测试的性能指标将 记录初始和绝对跛行距离的变化。