Statistical methods in clinical trials and epidemiology studies

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During the next five years, I will conduct research on the following topics: I am interested in developing new statistical methods for the analysis of clustered recurrent events in epidemiology and clinical trials. In many clinical studies, recurrent event data arise when certain event may occur repeatedly over a period of time. For example, in cardiovascular trails, strokes may occur repeatedly over time; cancer patients may experience recurrent metastases tumors; patients with organ transplant may experience multiple rejection episodes. I will study the nonparametric estimate of the cumulative mean function of cluster recurrent events. I will extend methods for clustered recurrent events data and exploit and estimate the correlation structure among clustered subjects.