ROLE OF CYTOKINES IN CMV/HIV-1 INFECTIONS

(1)项目目标：-研究细胞因子在CMV中的作用 疾病(2)实验方法：-研究TNF α在CMV中的作用 艾滋病合并巨细胞病毒性结肠炎患者的炎症反应。 - 研究中的作用 TGF-β和CMV感染的小鼠星形胶质细胞。 (3)主要发现： - CMV诱导AIDS结肠黏膜TNF α表达 患者 - MCMV能有效感染小鼠星形胶质细胞。 感染细胞表达TGF-β mRNA并分泌TGF-β 制备中的肽。

(1) Goals of Project: -To investigate the role of cytokines in CMV disease. (2) Experimental Approaches: - Study the role of TNFa in CMV induced inflammation in AIDS patients with CMV colitis. - Study the role of TGF-beta and CMV infection in murine astrocytes. (3) Major Findings: - CMV but not HIV-1 induced TNFa expression in colonic mucosa from AIDS patients. - Murine astrocytes could be productively infected with MCMV. Infected cells expressed TGF-beta mRNA and secreted TGF-beta peptide.Manuscript in preparation.