MECHANISM OF RECURRENT URINARY TRACT INFECTIONS IN WOMEN

女性复发性尿路感染的机制

• 批准号: 3746632
• 负责人: T A RUSSO
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3746632
• 关键词: Escherichia coli infections; disease /disorder proneness /risk; female; genetic strain; human subject; molecular pathology; pulsed field gel electrophoresis; relapse /recurrence; urinary tract infection

The urinary tract is one of the commonest sites for bacterial infection. Strains of E. coli are responsible for greater than 80-90% of these episodes. Urinary tract infections in young women account for an estimated 7 million office visits per annum and more thana billion dollars of direct medical costs. Further, 20% of women will develop frequent recurrences. Understanding the mechanisms through which recurrences occur and devising preventative strategies is thus of considerable importance and is presently poorly understood. We utilized pulsed-field gel electrophoresis, to evaluate E. coli strains prospectively collected from 23 women with recurrent urinary tract infections. A subgroup of 6 women was studied to determine whether bacterial persistence within the urinary tract occurs or whether the colon is a reservoir for reinfecting strains. We determined that: 1 ) Genotypes of isolates from a given individual with recurrent urinary tract infections are the same the majority of the time. 2)The majority of recurrences are due to bacterial reinfection, not persistence. 3)The faeces serves as the reservoir for re-infecting strains. These results have significant therapeutic implications for women with recurrent UTI. This project has been terminated at N.I.H.

尿路是细菌感染最常见的部位之一。 其中超过80%-90%是由大肠杆菌引起的。 剧集。据估计，年轻女性的尿路感染占 每年700万次办公室访问和超过10亿美元的直接 医疗费用。此外，20%的女性会出现频繁的复发。 了解复发发生的机制，并设计 因此，预防性战略具有相当重要的意义，而且 目前人们对此知之甚少。我们利用脉冲场凝胶电泳法， 评估从23名妇女中前瞻性收集的大肠杆菌菌株 反复的尿路感染。一个由6名女性组成的小组被研究为 确定细菌在尿路内滞留是否发生或 结肠是否是再次感染菌株的储存库。 我们确定：1)来自特定个体的分离株的基因类型 反复的尿路感染在大多数情况下都是一样的。 2)大多数复发是由于细菌再感染，而不是 坚持不懈。3)粪便是再次感染的蓄水池。 菌株。 这些结果对女性的治疗具有重要的意义 复发性尿路感染。这个项目已经在N.I.H.终止了。