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BASIC AND APPLIED RESEARCH IN PROTOZOAN DISEASES

原虫疾病的基础与应用研究

基本信息

批准号：
2060343
负责人：
Warren Douglas Johnson
金额：
$ 30万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-09-30 至 1998-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2060343
关键词：
antiprotozoal agents human subject leishmaniasis

项目摘要

Diseases caused by the Leishmania-Trypanosoma complex are of major importance in the Wester Hemisphere. The diseases exhibit marked variation in clinical manifestations yet, taxonomically, biochemically and immunologically, they maintain many similarities which may provide clues to pathogenesis. Control of these diseases will result from careful evaluation of pathogenic mechanisms, antimicrobial therapy, disease patterns, and methods of accurate diagnosis. This program project brings together basic science and clinical investigators from Cornell University Medical College and The Rockefeller University and respected Brazilian investigators from the University of Bahia and the University of Brasilia. The central focus of this collaborative effort is the integration of basic and applied clinical research. The major research areas include: 1) basic parasitology, immunobiology and pharmacology of Chagas' disease and leishmaniasis; 2) clinical disease patterns, epidemiology and genetics these disease; and 3) application of immunologic techniques for understanding pathogenesis and for reliable diagnosis. Central to this grant is the attempt to coordinate the activities of investigators from different disciplines to allow exchange of limited resources, to bring these investigators in contact with young researchers abroad, and to advance our understanding of important human diseases.

利什曼-锥虫复合体引起的疾病在西半球。这些疾病在临床上表现出显著的多样性。然而，从分类学、生化和免疫学的角度来看，它们保持许多相似之处，这可能为发病机制提供线索。控制这些疾病将是对致病机制进行仔细评估的结果，抗菌治疗、疾病模式和准确诊断的方法。这个项目汇集了基础科学和临床研究人员。来自康奈尔大学医学院和洛克菲勒大学来自巴伊亚大学和巴西利亚大学。这种协作工作的中心焦点是基础临床研究与应用临床研究相结合。主要研究领域内容包括：1)查加斯属植物的基本寄生学、免疫生物学和药理学疾病和利什曼病；2)临床疾病模式、流行病学和这些疾病的遗传学；3)免疫学技术的应用了解发病机制并进行可靠的诊断。这笔赠款的核心是试图协调来自不同国家的调查人员的活动学科允许交换有限的资源，让这些调查人员与国外的青年研究人员接触，增进我们对重要的人类疾病。