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HIV-MEDIATED REPRESSION OF MHC CLASS I GENE EXPRESSION

HIV-MEDIATED REPRESSION OF MHC CLASS I GENE EXPRESSION
HIV 介导的 MHC I 类基因表达抑制
批准号：
3752140
负责人：
D SINGER
金额：
$0.0万
依托单位：
DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3752140
关键词：
MHC class I antigen RNA splicing gene induction /repression genetic mapping genetic promoter element genetic transcription histocompatibility gene human immunodeficiency virus 1 nucleic acid repetitive sequence protein structure transcription factor virus genetics virus infection mechanism virus protein virus receptors

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英文摘要
MHC class I molecules are the major receptors for viral peptides and serve as targets for specific cytotoxic T lymphocytes. HIV-1 specifically decreased activity of an MHC class I gene promoter up to 12-fold. Repression was effected by the HIV-1 Tat protein derived from a spliced viral transcript (two-exon Tat). These studies define an activity for two- exon Tat distinct from that of one-exon Tat and suggest a mechanism whereby HIV-1-infected cells might be able to avoid immune surveillance, allowing the virus to persist in the infected host.
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