HYPERPARATHYROIDISM--ETIOLOGY, DIAGNOSIS AND TREATMENT

甲状旁腺功能亢进症——病因、诊断和治疗

• 批准号: 3754518
• 负责人: S J MARX
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3754518
• 关键词: angiography; artery; autologous transplantation; computed axial tomography; cryopreservation; cryoscience; endocrine disorder diagnosis; epidemiology; family genetics; genetic disorder; genetic disorder diagnosis; hormone regulation /control mechanism; human subject; human therapy evaluation; hyperparathyroidism; linkage mapping; magnetic resonance imaging; molecular pathology; multiple endocrine neoplasia; neoplasm /cancer epidemiology; neoplasm /cancer therapy; nucleic acid probes; parathyroid gland; parathyroid hormones; pathologic process; radioimmunoassay; radionuclide imaging /scanning; radionuclides; thallium; tissue /cell culture; tissue /organ preservation; ultrasonography

The project goal is the evaluation and treatment of hyperparathyroidism. Patients with persistent recurrent hyperparathyroidism are referred for evaluation and treatment. Hereditary hyperparathyroidism in particular is under investigation in the hopes of delineating hereditary molecular abnormalities in glandular regulation, as exemplified in the multiple endocrine neoplasia syndromes. Evaluation ranges from epidemiologic studies of families to in-house clinical studies of patients and to in vitro analyses of excised tissue. Techniques currently being employed and improved include radioimmunoassay of parathyroid hormone, ultrasonography, (reoperative and intra operative) radiothallium scanning, magnetic resonance imaging, CAT scanning, selective arteriography and selective venous sampling for parathyroid hormone, parathyroid gland cryopreservation and autotransplantation, and transcatheter parathyroid gland infarction. In vitro evaluation of parathyroid and other endocrine tissue involves tissue culture, chemistry and determination of linkage with DNA or RNA probes.

该项目的目标是评估和治疗甲状旁腺功能亢进症。 持续复发性甲状旁腺功能亢进的患者， 评估和治疗。 尤其是遗传性甲状旁腺功能亢进 正在进行调查，希望能描绘出遗传分子 腺体调节异常，如在多个 内分泌肿瘤综合征 评价范围从流行病学 从家庭研究到内部患者临床研究， 离体组织的体外分析。 目前采用的技术 并且改进了包括甲状旁腺激素的放射免疫测定， 超声检查，（再次手术和术中）放射性铊 扫描，磁共振成像，CAT扫描，选择性 动脉造影和选择性静脉取样检查甲状旁腺激素， 甲状旁腺冷冻保存和自体移植，以及 经导管甲状旁腺梗死 的体外评价 甲状旁腺和其他内分泌组织涉及组织培养、化学 以及与DNA或RNA探针的连接的测定。