HYPERPARATHYROIDISM--ETIOLOGY, DIAGNOSIS AND TREATMENT

甲状旁腺功能亢进症——病因、诊断和治疗

• 批准号: 6161974
• 负责人: S J MARX
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6161974
• 关键词: angiography; autologous transplantation; clinical research; computed axial tomography; cryopreservation; endocrine disorder diagnosis; endocrine transplantation; epidemiology; family genetics; genetic disorder; genetic disorder diagnosis; human subject; human therapy evaluation; hyperparathyroidism; magnetic resonance imaging; multiple endocrine neoplasia; parathyroid gland; pathologic process; radioimmunoassay; radionuclide imaging /scanning; technetium; tissue /cell culture; ultrasonography

The project goal is the evaluation and treatment of hyperparathyroidism. Patients with persistent or recurrent hyperparathyroidism are referred for evaluation and treatment. Hereditary hyperparathyroidism in particular is under investigation in the hopes of delineating hereditary molecular abnormalities in glandular regulation, as exemplified in the multiple endocrine neoplasia syndromes. Evaluation ranges from epidemiologic studies of families to in-house clinical studies of patients and to in vitro analyses of excised tissue. Techniques currently being employed and improved include radioimmunoassay of parathyroid hormone, ultrasonography, (reoperative and intra operative), technetium sestamibi scanning, magnetic resonance imaging, CAT scanning, selective arteriograpy and selective venous sampling for parathyroid hormone, parathyroid gland cryopreservation and autotransplantation, and transcatheter parathyroid gland infarction. In vitro evaluation of parathyroid and other endocrine tissue involves tissue culture, chemistry and determination of linage with DNA and RNA probes.

该项目的目标是评估和治疗甲状旁腺功能亢进症。 持续性或复发性甲状旁腺功能亢进的患者 进行评估和治疗。 遗传性高甲状旁腺素 特别是正在调查中，希望划定遗传 腺体调节的分子异常，如 多发性内分泌肿瘤综合征 评价范围从 家庭的流行病学研究到内部的临床研究， 患者和离体组织的体外分析。 技术 目前正在使用和改进的包括放射免疫测定法， 甲状旁腺激素，超声检查，（再次手术和术中）， 锝-甲氧基异丁基异腈扫描，磁共振成像，CAT扫描， 甲状旁腺选择性动静脉造影术 激素、甲状旁腺冷冻保存和自体移植，以及 经导管甲状旁腺梗死的体外评价 甲状旁腺和其它内分泌组织涉及组织培养， 化学和用DNA和RNA探针测定谱系。