Ion Mobility Mass Spectrometry Training Network

离子淌度质谱培训网络

基本信息

  • 批准号:
    EP/Y030877/1
  • 负责人:
  • 金额:
    $ 33.22万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2024
  • 资助国家:
    英国
  • 起止时间:
    2024 至 无数据
  • 项目状态:
    未结题

项目摘要

Ion mobility-high resolution mass spectrometry (IM-HRMS) is the next-generation analytical platform in research and industry. Unlocking its full potential across applications as varied as biotherapeutics, environment and food safety requires not only pushing back the frontiers of instrumentation, fundamental understanding and applications - but harmonisation is essential. To achieve this, current shortcomings in data collection, analysis and reporting across instrument types, laboratories and research areas need to be scrutinised and overcome.The MobiliTraIN Doctoral Network will form 10 Doctoral Candidates (DCs) who will bring a new fundamental understanding of IM- HRMS, provide reference materials and guidelines for standardisation, develop state-of-the-art methods for the application of IM- HRMS in biopharmaceutical development, biological 'omics studies, and nontarget screening of contaminants, and lay the foundations for IM-HRMS adoption in industry. Through an interdisciplinary research programme, including an open science approach and training in technical, business and transferable skills, the MobiliTraIN DCs will become leading experts in ion mobility with a unique skill set to successfully advance their careers while supporting Europe's innovation capacity.Building on existing collaborations and research excellence covering the entire innovation chain of IM-HRMS development and application, MobiliTraIN unites 8 academic institutions, 3 leading instrumentation companies, 1 regulatory agency, 1 pharma industry leader and 5 SMEs from 8 countries. With complementary expertise, know-how and mentoring experience, our consortium is ideally suited to unveil the potential of IM-HRMS as a key technology for safer therapeutics, better understanding of complex disease progression and improved monitoring of food, water and public health safety.
离子迁移率-高分辨率质谱(IM-HRMS)是研究和工业中的下一代分析平台。在生物治疗、环境和食品安全等各种应用中释放其全部潜力,不仅需要推动仪器、基本理解和应用的前沿,而且协调也至关重要。为了实现这一目标,目前在数据收集、分析和报告方面存在的缺陷需要在仪器类型、实验室和研究领域进行审查和克服。MobiliTraIN博士网络将形成10名博士候选人(DCs),他们将带来对IM-HRMS的新的基本理解,提供标准化的参考材料和指导方针,为IM-HRMS在生物制药开发、生物组学研究和污染物非靶筛选中的应用开发最先进的方法,并为IM-HRMS在工业中的应用奠定基础。通过跨学科的研究计划,包括开放科学方法和技术、商业和可转移技能的培训,MobiliTraIN DCs将成为离子流动性领域的领先专家,拥有独特的技能,成功地推进他们的职业生涯,同时支持欧洲的创新能力。在现有的合作和卓越研究的基础上,涵盖IM-HRMS开发和应用的整个创新链,MobiliTraIN联合了来自8个国家的8个学术机构、3家领先的仪器公司、1个监管机构、1个制药行业领导者和5家中小企业。凭借互补的专业知识,技术诀窍和指导经验,我们的联盟非常适合揭示IM-HRMS作为更安全治疗的关键技术的潜力,更好地了解复杂疾病的进展,并改善食品,水和公共卫生安全的监测。

项目成果

期刊论文数量(0)
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Perdita Barran其他文献

Classification of Parkinson’s disease and isolated REM sleep behaviour disorder: delineating progression markers from the sebum volatilome
帕金森病和孤立性快速眼动睡眠行为障碍的分类:从皮脂挥发组描绘进展标志物
  • DOI:
    10.1038/s41531-025-01026-8
  • 发表时间:
    2025-07-15
  • 期刊:
  • 影响因子:
    8.200
  • 作者:
    Caitlin Walton-Doyle;Beatrice Heim;Eleanor Sinclair;Sze Hway Lim;Katherine A. Hollywood;Joy Milne;Evi Holzknecht;Ambra Stefani;Birgit Högl;Klaus Seppi;Monty Silverdale;Werner Poewe;Perdita Barran;Drupad K. Trivedi
  • 通讯作者:
    Drupad K. Trivedi
Deciphering the safeguarding role of cysteine residues in p53 against H2O2-induced oxidation using high-resolution native mass spectrometry
使用高分辨率天然质谱法破译半胱氨酸残基在 p53 中对 H2O2 诱导的氧化的保护作用
  • DOI:
    10.1038/s42004-024-01395-w
  • 发表时间:
    2025-01-15
  • 期刊:
  • 影响因子:
    6.200
  • 作者:
    Manuel David Peris-Díaz;Artur Krężel;Perdita Barran
  • 通讯作者:
    Perdita Barran
Isoleucine/leucine<sup>2</sup> is essential for chemoattractant activity of β-defensin Defb14 through chemokine receptor 6
  • DOI:
    10.1016/j.molimm.2009.11.025
  • 发表时间:
    2010-03-01
  • 期刊:
  • 影响因子:
  • 作者:
    Christine Tyrrell;Martin De Cecco;Natalie L. Reynolds;Fiona Kilanowski;Dominic Campopiano;Perdita Barran;Derek Macmillan;Julia R. Dorin
  • 通讯作者:
    Julia R. Dorin
How storage post sampling influences the stability of sebum when used for mass spectrometry metabolomics analysis?
在用于质谱代谢组学分析时,储存后采样如何影响皮脂的稳定性?
  • DOI:
    10.1038/s41598-024-71598-7
  • 发表时间:
    2024-09-17
  • 期刊:
  • 影响因子:
    3.900
  • 作者:
    Caitlin Walton-Doyle;Eleanor Sinclair;Humayra Begum;Katherine A. Hollywood;Drupad K. Trivedi;Perdita Barran
  • 通讯作者:
    Perdita Barran
From Discovery to Delivery: A Rapid and Targeted Proteomics Workflow for Monitoring Chinese Hamster Ovary Biomanufacturing
从发现到交付:用于监测中国仓鼠卵巢生物制造的快速且有针对性的蛋白质组学工作流程
  • DOI:
    10.1016/j.mcpro.2025.101011
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    5.500
  • 作者:
    Charles Eldrid;Ellie Hawke;Kathleen M. Cain;Kate Meeson;Joanne Watson;Reynard Spiess;Luke Johnston;William Smith;Matthew Russell;Robyn Hoare;John Raven;Jean-Marc Schwartz;Magnus Rattray;Leon Pybus;Alan Dickson;Andrew Pitt;Perdita Barran
  • 通讯作者:
    Perdita Barran

Perdita Barran的其他文献

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{{ truncateString('Perdita Barran', 18)}}的其他基金

New Mass Spectrometry Methods to Characterise Virus Based Drug Products
表征病毒药物产品的新质谱方法
  • 批准号:
    BB/X002403/1
  • 财政年份:
    2023
  • 资助金额:
    $ 33.22万
  • 项目类别:
    Research Grant
Molecular mapping of SARS-CoV2 and the host response with multiomics mass spectrometry to stratify disease outcomes
利用多组学质谱分析 SARS-CoV2 的分子图谱和宿主反应,对疾病结果进行分层
  • 批准号:
    BB/V011456/1
  • 财政年份:
    2020
  • 资助金额:
    $ 33.22万
  • 项目类别:
    Research Grant
High Resolution High Throughput Mass Spectrometry to Characterise Materials, Chemicals, and BioCatalysts
用于表征材料、化学品和生物催化剂的高分辨率高通量质谱
  • 批准号:
    EP/T019328/1
  • 财政年份:
    2020
  • 资助金额:
    $ 33.22万
  • 项目类别:
    Research Grant
Hydrogen/Deuterium Exchange and Ion Mobility Mass Spectrometry to Underpin Research on Protein Interactions
氢/氘交换和离子淌度质谱支撑蛋白质相互作用研究
  • 批准号:
    BB/L015048/1
  • 财政年份:
    2014
  • 资助金额:
    $ 33.22万
  • 项目类别:
    Research Grant
Conformer selected Top Down Sequencing - A Novel Approach to Structural Proteomics
Conformer 选择的自上而下测序 - 结构蛋白质组学的新方法
  • 批准号:
    BB/L002655/1
  • 财政年份:
    2014
  • 资助金额:
    $ 33.22万
  • 项目类别:
    Research Grant

相似海外基金

High-Resolution Ion Mobility Mass Spectrometer for Complex Mixture Analysis
用于复杂混合物分析的高分辨率离子淌度质谱仪
  • 批准号:
    537609375
  • 财政年份:
    2024
  • 资助金额:
    $ 33.22万
  • 项目类别:
    Major Research Instrumentation
Ion mobility mass spectrometer
离子淌度质谱仪
  • 批准号:
    531416396
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    2024
  • 资助金额:
    $ 33.22万
  • 项目类别:
    Major Research Instrumentation
Ion Mobility Mass Spectrometry Training Network
离子淌度质谱培训网络
  • 批准号:
    EP/Y032845/1
  • 财政年份:
    2024
  • 资助金额:
    $ 33.22万
  • 项目类别:
    Research Grant
An ion mobility-mass spectrometry based platform for structural proteomics
基于离子淌度-质谱的结构蛋白质组学平台
  • 批准号:
    LE240100135
  • 财政年份:
    2024
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    $ 33.22万
  • 项目类别:
    Linkage Infrastructure, Equipment and Facilities
Ion mobility mass spectrometer with electrospray ionisation (ESI-IMS-MS) for protein analysis
用于蛋白质分析的电喷雾电离离子淌度质谱仪 (ESI-IMS-MS)
  • 批准号:
    531399310
  • 财政年份:
    2023
  • 资助金额:
    $ 33.22万
  • 项目类别:
    Major Research Instrumentation
Hybrid ESI/MALDI mass spectrometer with trapped ion mobility spectrometry
具有捕获离子迁移谱分析功能的混合 ESI/MALDI 质谱仪
  • 批准号:
    507957722
  • 财政年份:
    2023
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    $ 33.22万
  • 项目类别:
    Major Research Instrumentation
Characterising the role of ubiquitylation in endo-lysosomal trafficking by highly sensitive ion mobility mass spectrometry
通过高灵敏度离子淌度质谱表征泛素化在内溶酶体运输中的作用
  • 批准号:
    2882653
  • 财政年份:
    2023
  • 资助金额:
    $ 33.22万
  • 项目类别:
    Studentship
High resolution cyclic ion mobility HDX mass spectrometry of protein dynamics and function
蛋白质动力学和功能的高分辨率循环离子淌度 HDX 质谱分析
  • 批准号:
    MR/X013030/1
  • 财政年份:
    2023
  • 资助金额:
    $ 33.22万
  • 项目类别:
    Research Grant
Development of Multidimensional Ion Mobility-Tandem Mass Spectrometry (IMSn-FT-ICR MSn) Tools for the Characterization of Complex Mixtures
开发用于表征复杂混合物的多维离子淌度串联质谱 (IMSn-FT-ICR MSn) 工具
  • 批准号:
    2304837
  • 财政年份:
    2023
  • 资助金额:
    $ 33.22万
  • 项目类别:
    Standard Grant
Protein conformation, Protein misfolding, hIAPP, Ion mobility mass spectrometry
蛋白质构象、蛋白质错误折叠、hIAPP、离子淌度质谱
  • 批准号:
    2869746
  • 财政年份:
    2023
  • 资助金额:
    $ 33.22万
  • 项目类别:
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