Coupling the cell cortex to membranes: structural basis for the activation and control of ezrin

细胞皮层与膜的耦合：埃兹蛋白激活和控制的结构基础

• 批准号: nhmrc : 1085718
• 负责人: A/Pr Till Boecking
• 金额: $ 39.18万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/coupling-cell-cortex-control-ezrin/519099
• 关键词: Coupling; cell; cortex; membranes; structural

Cells are dynamic: they change shape, communicate with each other and import/export signalling molecules. These dynamic processes are controlled via the interaction of the cell membrane with the underlying actin cytoskeleton and they are important for health, for example, they are critical for proper immune cell function. The goal of this project in to unravel the control of membrane dynamics by defining the interactions between the cell membrane and the proteins: ezrin and RhoA.

细胞是动态的：它们改变形状、相互交流并输入/输出信号分子。这些动态过程是通过细胞膜与底层肌动蛋白细胞骨架的相互作用来控制的，它们对健康很重要，例如，它们对于正常的免疫细胞功能至关重要。该项目的目标是通过定义细胞膜与蛋白质（ezrin 和 RhoA）之间的相互作用来揭示膜动力学的控制。