Formin' actin filaments associated with cancer

形成与癌症相关的肌动蛋白丝

• 批准号: nhmrc : 1098870
• 负责人: A/Pr Till Boecking
• 金额: $ 41.93万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/formin-actin-filaments-associated-cancer/662406
• 关键词: Formin; actin; filaments; associated; cancer

Actin filaments are part of a dynamic network of protein fibres inside each cell and play a role in cell shape, movement and division. Cancer cells hijack specific types of actin filaments to spread throughout the body. Our aim is to find out how protein machines assemble these filaments from actin and different binding proteins that give each filament its specific function. This insight will allow us to improve drugs that inhibit filaments associated with cancer.

肌动蛋白细丝是每个细胞内蛋白质纤维动态网络的一部分，在细胞的形状、运动和分裂中发挥作用。癌细胞劫持特定类型的肌动蛋白细丝，使其扩散到全身。我们的目标是找出蛋白质机器如何从肌动蛋白和不同的结合蛋白中组装这些细丝，这些结合蛋白赋予每个细丝特定的功能。这种洞察力将使我们能够改进抑制与癌症相关的细丝的药物。