Characterize the post-entry events of HIV infection

描述 HIV 感染后的事件特征

• 批准号: nhmrc : 1025273
• 负责人: A/Pr Till Boecking
• 金额: $ 40.35万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterize-post-entry-hiv-infection/110423
• 关键词: Characterize; post; entry; events; HIV

For HIV to successful infect a target cell, it must properly remove the outer layers of its protective gears (outer viral protein coats) to allow the viral genetic materials to be replicate (duplicate and multiplied) for the generation of their ‘offspring viruses’. This process is known as viral uncoating, and it is arguably one of the least understood areas of HIV. In this proposal, we will use a number of complementary state-of-the-arts research tools to characterize the HIV uncoating process.

为了使HIV成功感染靶细胞，它必须适当地去除其保护装置的外层（外部病毒蛋白质外壳），以允许病毒遗传物质被复制（复制和繁殖）以产生它们的“后代病毒”。这个过程被称为病毒脱壳，可以说是HIV最不了解的领域之一。在本提案中，我们将使用一些补充性的最先进的研究工具来描述艾滋病毒的脱壳过程。