STUDY OF A MURINE RETROVIRUS FROM A PACKAGING CELL LINE USED IN GENE THERAPY
STUDY OF A MURINE RETROVIRUS FROM A PACKAGING CELL LINE USED IN GENE THERAPY
批准号:
3770323
负责人:
A S KHAN
金额:
$0.0万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Macaca mulatta Retroviridae artificial immunosuppression blood chemistry disease /disorder model disease /disorder proneness /risk gene therapy juvenile animal lymphoma neoplasm /cancer genetics polymerase chain reaction tissue /cell culture viral carcinogenesis viral rescue virus DNA virus diseases virus genetics virus replication western blottings
中文摘要
复制能力小鼠逆转录病毒(RCRs)可以在一些
英文摘要
Replication-competent murine retroviruses (RCRs) can be generated in some
cases from packaging cell lines used in preparation of gene therapy product
generated for human use. Since the risk associated with RCR in man is
unknown, rigorous testing for RCRs is recommended to exclude possible
contamination of the product. Previous studies in which normal and
moderately immunosuppressed monkeys were inoculated with RCR indicated rapi
virus clearance and no pathology (Cornetta et al, 1991); however, a recent
study has shown RCR to be associated with development of lymphomas in
severely immunosuppressed rhesus monkeys (Donahue et al, 1992). To assess
the potential risk of RCRs in man, we undertook to analyze the role of RCRs
in infection and lymphomagenesis using monkeys as a primate model system.
Four normal juvenile rhesus monkeys were inoculated with a RCR preparation
obtained from Genetic Therapy Inc. Studies are in progress to analyze the
monkeys for infectivity using blood samples obtained every two weeks post-
inoculation: PBLs are tested for virus isolation; plasma is obtained for
antibody detection by Western blot analysis; DNAs are prepared from PBLs fo
analysis of viral DNA by PCR. In addition clinical hematology and serum
chemistry is being performed.
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STRUCTURAL AND FUNCTIONAL STUDIES OF MAMMALIAN ENDOGENOUS RETROVIRAL SEQUENCES
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批准号:3818206
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:
STRUCTURAL AND FUNCTIONAL STUDIES OF MAMMALIAN ENDOGENOUS RETROVIRAL SEQUENCES
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批准号:3809632
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:
DEVELOPMENT OF A MONKEY MODEL FOR TESTING OF ANTIVIRAL AGENTS AGAINST HIV-1
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批准号:3770322
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:--
STRUCTURAL AND FUNCTIONAL ANALYSIS OF ENDOGENOUS PROVIRUSES OF MICE
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批准号:3822045
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:
DEVELOPMENT OF A MONKEY MODEL FOR TESTING OF ANTIVIRAL AGENTS AGAINST HIV-1
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批准号:5200716
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:--
DEVELOPMENT OF A MONKEY MODEL FOR TESTING OF ANTIVIRAL AGENTS AGAINST HIV-1
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批准号:3748151
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:--
STUDY OF A MURINE RETROVIRUS FROM A PACKAGING CELL LINE USED IN GENE THERAPY
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批准号:3748152
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:--
MOLECULAR ANALYSIS OF MAMMALIAN ENDOGENOUS RETROVIRAL SEQUENCES
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批准号:3792555
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:--
STRUCTURAL AND FUNCTIONAL STUDIES OF MAMMALIAN ENDOGENOUS RETROVIRAL SEQUENCES
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批准号:3790737
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:
MOLECULAR BIOLOGY AND BIOCHEMICAL STRUCTRUE OF ENDOGENOUS PROVIRUSES OF MICE
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批准号:4688492
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:
STUDY OF A MURINE RETROVIRUS FROM A PACKAGING CELL LINE USED IN GENE THERAPY
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批准号:5200717
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:--
STRUCTURAL AND FUNCTIONAL ANALYSIS OF ENDOGENOUS PROVIRUSES OF MICE
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批准号:3960567
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:
MONKEY MODEL FOR AIDS
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批准号:3792554
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A S KHAN
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依托单位:--