MONKEY MODEL FOR AIDS

人类免疫缺陷病毒(HIV-1)会导致人类感染艾滋病。它的猿猴 对应物(SIV)在亚洲猴子中诱导一种类似艾滋病的疾病。这个 HIV-1感染和疾病动物模型系统的建立 对于艾滋病疫苗研究和干预是必不可少的。目前， 唯一可能感染HIV-1的动物物种是黑猩猩； 然而，不会产生疾病。由于巨大的成本， 养一只黑猩猩，以及这不会成为疾病的事实 为了找到更好的模型，人们找到了一种更好的模型。根据最近一份来自 华盛顿灵长类动物研究中心，我们承担了调查研究 猪尾猴的HIV-1感染。最初，我们正在测试 不同HIV-1分离株体外培养猪尾淋巴细胞的感染性 包括野外分离株(&lt；4代)以及一些实验室- 适应的菌株。由于北美大多数HIV-1分离株 在env区的V3环中，我们的目标是接种疫苗 并展示了对类似“MN”的HIV-1分离株的保护。

The human immunodeficiency virus (HIV-1) causes AIDS in man. Its simian counterpart (SIV) induces an AIDS-like disease in Asian monkeys. The development of an animal model system for infection and disease by HIV-1 is essential for AIDS vaccine studies and intervention. Currently, the only animal species which can be infected by HIV-1 is the chimpanzee; however, no disease is produced. Due to the enormous cost of maintaining a chimpanzee and the fact that this cannot be a disease model, a better model was sought. Based upon a recent report from the Washington Primate Research Center, we undertook studies to investigate HIV-1 infection in pig-tail monkeys. Initially, we are testing infectivity of pig-tail PBLs in vitro using various HIV-1 isolates including field isolates (< 4 passages) as well as some laboratory- adapted strains. Since the majority of North American HIV-1 isolates are "MN"-like in the V3 loop of the env region, our aim is to vaccinate and demonstrate protection against an "MN"-like HIV-1 isolate.