PHOTOTHERAPY OF INTRACAVITARY SPACES

血卟啉衍生物和其它光敏剂的用途 目前正在研究与光活化相结合， 一种用于治疗腹膜内肿瘤的抗肿瘤方式， 胸内肿瘤 这种方式的一个主要优点是明显的 选择性保留肿瘤的敏化染料。 起初， 用小鼠模型研究胸腔耐受性 正在探索的光疗技术的结构。 的 鼠模型的局限性要求扩展 用犬模型评价复方丹参注射液的毒性 光疗。 不同波长的光，不同的激光传输 系统，不同的敏化剂，不同的能量剂量，不同的 给药方式和不同的监测设备， 研究了 我们已经将毒性研究扩展到犬胸腔 研究表明，食道、壁骨和内脏等结构 胸膜、心脏可耐受35 J.cm2红光。 无胸腺小鼠模型 移植的人肺癌用于研究光免疫疗法。 血卟啉与特异性单克隆抗体共价结合 针对异种移植物。 结果表明，肿瘤可以 根除并消除皮肤光毒性。 我们有 感兴趣的是确认其他人的工作，以确定是否超声波 在小鼠系统中激活Hp是一个合理的研究领域 努力

The use of hematoporphyrin derivative and other photosensitizing agents in combination with light activation is currently being investigated as an anti-tumor modality for the treatment of intraperitoneal and intrathoracic tumors. A major advantage of this modality is the apparent selective retention of the sensitizing dye with tumors. Initially, murine models were used to study the tolerance of the thoracic cavity structures to the phototherapy techniques being explored. The limitations of the murine model has required the extensions of the investigation to the canine model for evaluation of the toxicity of Phototherapy. Different wavelengths of light, different laser delivery systems, different sensitizers, different doses of energy, different modes of drug administration, and different monitoring devices were studied. We have extended a toxicity study to the canine thoracic cavity and shown that structures such as the esophagus, parietal and visceral pleura, heart can tolerate 35 J.cm2 red light. An athymic murine model transplanted with human lung cancer was used to study photoimmunotherapy. Hematoporphyrin was covalently bound to the specific monoclonal antibody directed against the xenograft. The results show that tumor can be eradicated and that dermatophototoxicity is eliminated. We have had interest in confirming work by others to determine if ultrasonic activation of Hp in murine systems is a reasonable area of research effort.