MECHANISMS OF RADIOPROTECTION

辐射防护机制

• 批准号: 4692120
• 负责人: A RUSSO
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4692120
• 关键词: X ray; bacteria; cell membrane; detoxification; drug design /synthesis /production; glutathione; lymphocyte; radiation hazard; radiation sensitivity; radiopharmacology; radioprotective agents; thiols

Thiols have long been studied as radioprotective compounds, yet the mechanism of protection is still poorly understood. We have developed means by which the major cellular thiol, glutathione, can be either depleted or elevated and then access radiosensitivity. We have shown that glutathione is not a major protector for x-ray. Plans are to synthesize compounds varying in chemical structure that may provide radioprotection. The importance of separate thiol dependent detoxification enzymes versus general oxidative detoxification is being studied. The use of bacteria with great radiation sensitivity is being studied to determine the uniqueness of this model.

硫醇作为防辐射化合物早已被研究，然而