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MECHANISMS OF RADIOPROTECTION

MECHANISMS OF RADIOPROTECTION
辐射防护机制
批准号:
4692120
负责人:
A RUSSO
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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中文摘要
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英文摘要
Thiols have long been studied as radioprotective compounds, yet the mechanism of protection is still poorly understood. We have developed means by which the major cellular thiol, glutathione, can be either depleted or elevated and then access radiosensitivity. We have shown that glutathione is not a major protector for x-ray. Plans are to synthesize compounds varying in chemical structure that may provide radioprotection. The importance of separate thiol dependent detoxification enzymes versus general oxidative detoxification is being studied. The use of bacteria with great radiation sensitivity is being studied to determine the uniqueness of this model.
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会议论文
INTRACELLULAR MODULATION OF SPECIFIC INTRACELLULAR PROTEINS
RELATIONSHIP OF CELLULAR REDOX STATE AND THERMOTOLERANCE
  • 批准号:
    3939515
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    A RUSSO
  • 依托单位:
INTRACELLULAR MODULATION OF SPECIFIC INTRACELLULAR PROTEINS
  • 批准号:
    3752415
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    A RUSSO
  • 依托单位:
DEVELOPMENT OF SUPEROXIDE DISMUTASE MIMICS
  • 批准号:
    3774576
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    A RUSSO
  • 依托单位:
国内基金
海外基金
Segmented Filamentous Bacteria激活宿主免疫系统抑制其拮抗菌 Enterobacteriaceae维持菌群平衡及其机制研究
  • 批准号:
    81971557
  • 项目类别:
    面上项目
  • 资助金额:
    65.0万元
  • 批准年份:
    2019
  • 负责人:
    毛开睿
  • 依托单位:
电缆细菌(Cable bacteria)对水体沉积物有机污染的响应与调控机制