PHOTOTHERAPY OF INTRACAVITARY SPACES
PHOTOTHERAPY OF INTRACAVITARY SPACES
批准号:
3853179
负责人:
A RUSSO
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
athymic mouse combination cancer therapy disease /disorder model dogs drug administration routes drug delivery systems drug screening /evaluation heme laboratory mouse laser therapy light adverse effect luminescence malignant ascites mesothelioma neoplasm /cancer immunotherapy neoplasm /cancer photoradiation therapy nonvisual photosensitivity ovary neoplasms peritoneum neoplasm pharmacokinetics photosensitizing agents porphyrins radiation therapy dosage thorax neoplasm tissue /cell culture
中文摘要
血卟啉衍生物及其它光敏剂的使用
英文摘要
The use of hematoporphyrin derivative and other photosensitizing agents
in combination with light activation is currently being investigated as
an anti-tumor modality for the treatment of intraperitoneal and
intrathoracic tumors. A major advantage of this modality is the
apparent selective retention of the sensitizing dye within tumors. A
murine ascites ovarian carcinoma and a human ovarian tumor have been
used to study the characteristics of drug distribution in the peritoneal
cavity. Initially, murine models were used to study the tolerance of
the thoracic cavity structures to the phototherapy techniques being
explored. The limitations of the murine model has required the
extensions of the investigation to the canine model for evaluation of
the toxicity of Phototherapy. Different wavelengths of light, different
laser delivery systems, different sensitizers, different doses of
energy, different modes of drug administration, and different monitoring
devices were studied. We have shown that Phototherapy can be used to
effectively treat a murine ascites tumor. We have also shown that in
both the murine and the canine model, the peritoneal serosal surface is
tolerant of at least 0.5 J/cm2 and that this work can be extended to
human subjects. In the murine system, we have shown that the thoracic
cavity, like the peritoneal cavity, is exquisitely sensitive to
treatment with red light (630 nm). The dose rate must be controlled to
minimize heat buildup (less than 150 mW fiber output from a forward
projecting optical fiber is usually tolerated). We have extended a
toxicity study to the canine thoracic cavity and shown that structures
such as the esophagus, parietal and visceral pleura, heart can tolerate
35 J/cm2 red light. Currently, there is an ongoing Phase I trial using
DHE/630nm light to treat unresectal mesothelioma. Currently, 32.5J/cm
has been used in the clinical treatment of mesothelioma. We are
exploring the use of photoimmunotherapy as an additional means of drug
delivery. An athymic murine model transplanted with human lung cancer
was used to study photoimmunotherapy. Hematoporphrin was covalently
bound to the specific monoclonal antibody directed against the
xenograft. The results show that tumor can be eradicated and that
dermatophotoxicity is eliminated. We are exploring the use of
chemiluminescence as a means of light delivery to the cavitary spaces.
A new class of water soluble agents arc being used. New forms of energy
delivery for activation of sensitizer are being explored.
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会议论文
INTRACELLULAR MODULATION OF SPECIFIC INTRACELLULAR PROTEINS
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批准号:2464488
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
RELATIONSHIP OF CELLULAR REDOX STATE AND THERMOTOLERANCE
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批准号:3939515
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
INTRACELLULAR MODULATION OF SPECIFIC INTRACELLULAR PROTEINS
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批准号:3752415
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
DEVELOPMENT OF SUPEROXIDE DISMUTASE MIMICS
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批准号:3774576
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
NITROXIDES AS PROTECTORS AGAINST OXIDATIVE STRESS
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批准号:3752336
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
PHOTOTHERAPY OF INTRACAVITARY SPACES
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批准号:3916586
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
MECHANISMS OF RADIOPROTECTION
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批准号:4692120
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
RELATIONSHIP OF CELLULAR REDOX STATE AND THERMOTOLERANCE
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批准号:3963241
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
MOLECULAR BIOLOGY--TISSUE CULTURE CORE FACILITY
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批准号:3854423
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
MOLECULAR BIOLOGY--TISSUE CULTURE CORE FACILITY
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批准号:3896917
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
NITROXIDES AS PROTECTORS AGAINST OXIDATIVE STRESS
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批准号:5201260
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
PHOTOTHERAPY OF MURINE OVARIAN CANCER BY HEMATOPORPHYRIN DERIVATIVE
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批准号:3963251
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
PULSE WAVE EPR SPECTROSCOPY AND IMAGING
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批准号:3838141
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
PHOTOTHERAPY OF INTRACAVITARY SPACES
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批准号:3838057
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
PHOTOTHERAPY OF INTRACAVITARY SPACES
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批准号:3774572
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
PULSE WAVE EPR SPECTROSCOPY AND IMAGING
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批准号:3774658
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
REDIRECTION OF REDOX PROTEINS TO THE NUCLEUS OF EUKARYOTIC CELLS
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批准号:3752414
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
RESPONSE OF MAMMALIAN CELLS TO CHEMOTHERAPY DRUGS
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批准号:3939509
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
RESPONSE OF MAMMALIAN CELLS TO CHEMOTHERAPY DRUGS
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批准号:3916572
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
INTRACELLULAR MODULATION OF SPECIFIC INTRACELLULAR PROTEINS
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批准号:6163331
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A RUSSO
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依托单位:
海外基金