STUDY OF SURGERY AND PHOTODYNAMIC THERAPY FOR INTRAPERITONEAL SARCOMAS

腹膜内肉瘤的手术和光动力治疗研究

• 批准号: 3774583
• 负责人: P OKUNIEFF
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774583
• 关键词: clinical trials; combination cancer therapy; human subject; human therapy evaluation; neoplasm /cancer photoradiation therapy; neoplasm /cancer relapse /recurrence; neoplasm /cancer surgery; peritoneum neoplasm; photosensitizing agents; porphyrins; radiation therapy dosage; sarcoma

Visceral sarcomas frequently develop multi-focal involvement of the peritoneal cavity. Similarly patients with retroperitoneal sarcomas can also develop multi-focal sarcoma of the peritoneal cavity. There's no effective treatment strategy for either of these problems. In a prior study (Z01 CM 0693-02 RO, Study of Surgery and Photodynamic Therapy for Intraperitoneal Malignancies), we develop the technique and defined the maximum tolerated dose of photodynamic therapy that could be delivered to the peritoneal surface. As a natural extension of that prior study, we are moving forward with this Phase II Study of Resection and Intraoperative Photodynamic Therapy for Intraperitoneal Sarcomatosis or Recurrent Retroperitoneal Sarcomas. Patients receive the dihematoporphyrin ethers photosensitizer 2.5 mg/kg 48 hours prior to a surgical procedure which involves surgical removal of tumor and intraoperative light delivery for photodynamic effect to the entire peritoneal surface.

内脏肉瘤经常发展为多灶性累及 腹腔 同样，腹膜后肉瘤患者可以 也会发展成腹膜腔的多灶性肉瘤。 没有 有效的治疗策略。 在现有 研究（Z 01 CM 0693-02 RO，手术和光动力疗法用于 腹膜内肿瘤），我们开发了该技术，并定义了 可输送的光动力治疗的最大耐受剂量 腹膜表面。作为先前研究的自然延伸， 我们正在进行切除术的第二阶段研究， 术中光动力疗法治疗腹膜内肉瘤或 复发性腹膜后肉瘤。 患者接受 二血卟啉醚类光敏剂2.5 mg/kg，给药前48小时 涉及手术切除肿瘤的外科手术， 术中光输送对整个 腹膜表面。