CLINICAL STUDIES ON INTRAOPERATIVE RADIATION THERAPY

术中放射治疗的临床研究

• 批准号: 5201256
• 负责人: P OKUNIEFF
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201256
• 关键词: carcinoma; clinical trials; electron radiation; human subject; human therapy evaluation; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; pancreas neoplasms; radiation therapy dosage; sarcoma; stomach neoplasms

The Radiation Oncology Branch and Surgery Branch of the National Cancer Institute have been involved in prospectively randomized studies evaluating the potential role of intraoperative radiation therapy in several disease sites, including resectable and unresectable carcinomas of the pancreas, resectable carcinomas of the stomach and retroperitoneal sarcomas. One hundred patients have been treated with experimental intraoperative radiation therapy, and randomized to either receive or not receive radiation therapy intraoperatively with large single doses of electrons. There is really no suggestion of improvement in survival, or in disease-free survival. There is some suggestion of an improvement of local control in the retroperitoneum itself; however, this is off-set by a high predilection for seeding of the abdominal cavity, either peritoneal carcinomatosis or sarcomatosis, thus neutralizing the potential benefit of intraoperative radiation. These trials are open for follow-up of therapy of previously studied patients.

国家癌症放射肿瘤学分会和外科分会 研究所已经参与了前瞻性随机研究 评价术中放射治疗的潜在作用 几个病变部位，包括可切除和不能切除的癌 胰腺、可切除的胃癌和腹膜后癌 肉瘤。已有100名患者接受了实验性的 术中放射治疗，随机接受或不接受 术中接受大剂量单次放射治疗 电子。确实没有任何迹象表明存活率有所提高，或者 在无病生存方面。有一些建议可以改善…… 腹膜后自身的局部控制；然而，这被 极易植入腹膜或腹膜的腹腔 癌病或肉瘤病，从而抵消了 术中放射治疗。这些试验对后续的治疗开放。 以前研究过的患者。