PENTOXIFYLLINE FOR RADIATION INDUCED ADVANCED REGIONAL FIBROSIS

己酮可可碱治疗辐射引起的晚期区域纤维化

• 批准号: 5201331
• 负责人: P OKUNIEFF
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201331
• 关键词: antineoplastics; collagen; cytokine; drug adverse effect; fibrosis; human subject; human therapy evaluation; inflammation; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; theobromine; tumor necrosis factor alpha

Pentoxifylline is a drug shown in AIDS and cancer patients to reduce TNF in those patients with elevated levels. It reduces inflammation via several mechanisms. It also decreases any hyper-coagulability of blood in radiation damaged blood vessels. Finally, in a small study 85% of radiation induced ulcers healed after pentoxifylline treatment. For these and other reasons we think that patients who manifest late effects of radiation or of combined radiation and surgery might benefit from this drug. We will follow blood cytokine levels and in some patients measure blood flow and collagen type in affected tissues to establish the mechanism of drug effect.

己酮茶碱是一种在艾滋病和癌症患者中显示可以降低肿瘤坏死因子的药物