NATURAL HISTORY OF ORAL MANIFESTATIONS OF HIV INFECTION

HIV 感染口腔表现的自然史

• 批准号: 3775678
• 负责人: P A SWANGO
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3775678
• 关键词: HIV infections; candidiasis; disease /disorder proneness /risk; helper T lymphocyte; histopathology; human subject; longitudinal human study; military personnel; opportunistic infections; oral leukoplakia; oral mucosa; periodontium disorder; saliva; serology /serodiagnosis

United States military personnel and dependents who have tested seropositive for the Human Immunodeficiency Virus (HIV) are given medical examinations and treatment at Walter Reed Army Medical Center. Subjects are also invited to participate in a research protocol to study the natural history of HIV infection, conducted by the Walter Reed Army Institute of Research. An oral health research component conducted by NIDR is a part of this natural history study. The oral component documents the prevalence and incidence of oral pathologic conditions in relation to the stage of HIV infection and systemic disease. Risk factors associated with these conditions are also characterized, and the role of oral manifestations as early predictors or markers of disease progression are studied. Areas of emphasis are mucosal diseases, periodontal conditions, candidal infections, and salivary constituents. Results to date show an increase in mucosal lesions as T4 cell counts decrease with progression of HIV disease. The most commonly observed mucosal lesions were oral candidiasis and hairy leukoplakia. Destructive periodontal disease has occurred in about 25 percent of subjects examined. Longitudinal studies showed that about 30% of persons free from mucosal diseases at entry presented with oral lesions after six months of follow-up.

参加过测试的美国军人及其家属 人类免疫缺陷病毒（HIV）血清反应呈阳性者 在沃尔特里德陆军医疗中心进行体检和治疗。 还邀请受试者参加研究方案， 研究艾滋病毒感染的自然史，由沃尔特 里德陆军研究所。 口腔健康研究部分 由NIDR进行的是这项自然历史研究的一部分。 口腔部分记录了口腔疾病的患病率和发病率， 与HIV感染阶段相关的病理状况， 全身性疾病。 与这些疾病相关的风险因素是 也有特点，和口腔的作用表现为早期 研究疾病进展的预测因子或标志物。 领域 重点是粘膜疾病、牙周病、念珠菌病 感染和唾液成分。 迄今为止的结果显示， 随着T4细胞计数随疾病进展而减少，粘膜病变增加 艾滋病病毒感染。 最常见的粘膜病变是口腔 念珠菌病和毛状白斑。 牙周病的危害有哪些 发生在大约25%的受试者身上。 纵向 研究表明，约30%的人没有粘膜疾病， 在6个月的随访后出现口腔病变。