NATURAL HISTORY OF ORAL MANIFESTATIONS OF HIV INFECTION

HIV 感染口腔表现的自然史

• 批准号: 3854219
• 负责人: P A SWANGO
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3854219
• 关键词: HIV infections; candidiasis; communicable disease transmission; disease /disorder proneness /risk; human subject; longitudinal animal study; military personnel; opportunistic infections; oral leukoplakia; oral mucosa; periodontium disorder; saliva; serology /serodiagnosis; sign /symptom

United States Army personnel and dependents who have tested seropositive for the Human Immunodeficiency Virus (HIV) are given medical examinations and treatment at the Walter Reed Army Medical Center. Subjects are also invited to participate in a research protocol to study the natural history of HIV infection, conducted by the Walter Reed Army Institute of Research. An oral health research component conducted by NIDR is a part of this natural history study. The oral component documents the prevalence and incidence of oral pathologic conditions in relation to the stage of HIV infection and systemic disease. Risk factors associated with these conditions are also characterized, and the role of oral manifestations as early predictors or markers of disease progression are studied. Areas of emphasis are mucosal pathologies, periodontal conditions, candidal infections, and salivary constituents. Results to date show an increase in mucosal pathology as T4 cell counts decrease with progression of HIV disease. The most commonly observed mucosal pathologies were oral candidiasis and hairy leukoplakia. Destructive periodontal disease has occurred in about 25 percent of subjects examined. Longitudinal studies showed that about 30% of persons free from mucosal pathology at entry presented with pathology after six months of follow-up.

检测血清呈阳性的美国陆军人员和家属 对人类免疫缺陷病毒(HIV)进行体检 在沃尔特里德陆军医疗中心接受治疗。科目也是 受邀参加一项研究方案，以研究自然历史 由沃尔特里德陆军研究所进行的关于艾滋病毒感染的研究。 由NIDR进行的口腔健康研究部分就是其中的一部分 自然史研究。 口腔部分记录了口腔疾病的患病率和发病率 与HIV感染阶段有关的病理情况和 系统性疾病。与这些情况相关的风险因素还包括 特征的，以及口腔表现作为早期预测或 研究疾病进展的标记物。强调的领域是粘膜 病理、牙周状况、念珠菌感染和唾液 选民。到目前为止的结果显示，随着T4的增加，粘膜病理增加 细胞计数随着HIV疾病的进展而减少。最常见的 黏膜病理表现为口腔念珠菌病和毛状白斑。 破坏性牙周病发生在约25%的 受试者接受检查。纵向研究表明，大约30%的人 入场时无粘膜病变，六点后出现病理 几个月的跟踪调查。