NATURAL HISTORY OF ORAL MANIFESTATIONS OF HIV INFECTION

美国陆军人员和家属谁测试血清阳性 艾滋病病毒感染者进行体检 在沃尔特里德陆军医疗中心接受治疗 受试者也 被邀请参加一项研究协议， 这项研究是由沃尔特里德陆军研究所进行的。 NIDR进行的口腔健康研究是其中的一部分 自然历史研究。 口腔部分记录了口腔疾病的患病率和发病率， 与HIV感染阶段相关的病理状况， 全身性疾病。 与这些疾病相关的风险因素也是 特征，以及口腔表现作为早期预测因子或 研究疾病进展的标志物。 重点领域是粘膜 病理学、牙周病、念珠菌感染和唾液 选民。 迄今为止的结果显示，随着T4 细胞计数随着艾滋病毒疾病的进展而减少。 最常见的 观察到的粘膜病理是口腔念珠菌病和毛状白斑。 破坏性牙周病发生在约25%的 检查的科目。 纵向研究表明，大约30%的人 入组时无粘膜病理学，6天后出现病理学 数月的随访。

United States Army personnel and dependents who have tested seropositive for the Human Immunodeficiency Virus (HIV) are given medical examinations and treatment at the Walter Reed Army Medical Center. Subjects are also invited to participate in a research protocol to study the natural history of HIV infection, conducted by the Walter Reed Army Institute of Research. An oral health research component conducted by NIDR is a part of this natural history study. The oral component documents the prevalence and incidence of oral pathologic conditions in relation to the stage of HIV infection and systemic disease. Risk factors associated with these conditions are also characterized, and the role of oral manifestations as early predictors or markers of disease progression are studied. Areas of emphasis are mucosal pathologies, periodontal conditions, candidal infections, and salivary constituents. Results to date show an increase in mucosal pathology as T4 cell counts decrease with progression of HIV disease. The most commonly observed mucosal pathologies were oral candidiasis and hairy leukoplakia. Destructive periodontal disease has occurred in about 25 percent of subjects examined. Longitudinal studies showed that about 30% of persons free from mucosal pathology at entry presented with pathology after six months of follow-up.