ORAL MANIFESTATION OF HIV INFECTION IN U S MILITARY POPULATION

美国军人艾滋病毒感染的口腔表现

• 批准号: 3917155
• 负责人: P A SWANGO
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3917155
• 关键词: HIV infections; candidiasis; communicable disease transmission; disease /disorder proneness /risk; human immunodeficiency virus 1; human subject; military personnel; mouth; oral leukoplakia; saliva; sign /symptom

United States Army personnel who have been tested as seropositive for the Human Immunodeficiency Virus (HIV) will be given medical examinations and treatment at Walter Reed Army Medical Center (WRAMC). These subjects will also be given the opportunity to participate in a medical research protocol to study the natural history of HIV infection, administered by the Walter Reed Army Institute of Research (WRAIR - see attached protocol). An oral component has been developed by staff of the National Institute of Dental Research (NIDR) in collaboration with U.S. Army medical and dental staff at WRAMC and WRAIR. Under the existing WRAIR natural history portocol, the oral examination is limited to the identification of pseudomembranous candidiasis (thrush), hairy leukoplakia, and the detection of enlarged lymph nodes in the head and neck region. The addition of the oral component will permit documentation of the prevalence and incidence of the full range of oral conditions in relation to the stage of HIV infection and systemic disease. Risk factors associated with these conditions will also be characterized, and the role of oral manifestations as early predictors or markers of disease progression will be elucidated. Finally, the role of saliva in the transmission of the virus will be investigated.

血清检测呈阳性的美国陆军人员 人类免疫缺陷病毒（HIV）将获得医疗 沃尔特里德陆军医疗中心的检查和治疗 （WRAMC）。 这些科目也将有机会 参加一项医学研究协议，研究自然 HIV感染史，由沃尔特里德陆军管理 研究所（WRAIR -见所附方案）。 口头 该组成部分已由国家研究所的工作人员开发， 牙科研究（NIDR）与美国陆军医疗和 WRAMC和WRAIR的牙科工作人员。 在现有的WRAIR自然历史门户下， 检查仅限于识别假膜性 念珠菌病（鹅口疮），毛状白斑，和检测 头颈部淋巴结肿大 添加 口头部分将允许记录患病率， 所有口腔疾病的发生率与 HIV感染和全身性疾病阶段。 危险因素 与这些条件相关的特征， 口腔表现作为早期预测或标记物的作用 将阐明疾病进展。 最后， 唾液中的病毒传播将进行调查。