NATURAL HISTORY OF ORAL MANIFESTATIONS OF HIV INFECTION

HIV 感染口腔表现的自然史

• 批准号: 3839221
• 负责人: P A SWANGO
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3839221
• 关键词: HIV infections; candidiasis; disease /disorder proneness /risk; helper T lymphocyte; histopathology; human subject; longitudinal human study; military personnel; opportunistic infections; oral leukoplakia; oral mucosa; periodontium disorder; saliva; serology /serodiagnosis

United States Army personnel and dependents who have tested seropositive for the Human Immunodeficiency Virus (HIV) are given medical examinations and treatment at Walter Reed Army Medical Center. Subjects are also invited to participate in a research protocol to study the natural history of HIV infection, conducted by the Walter Reed Army Institute of Research. An oral health research component conducted by NIDR is a part of this natural history study. The oral component documents the prevalence and incidence of oral pathologic conditions in relation to the stage of HIV infection and systemic disease. Risk factors associated with these conditions are also characterized, and the role of oral manifestations as early predictors or markers of disease progression are studied. Areas of emphasis are mucosal pathologies, periodontal conditions, candidal infections, and salivary constituents. Results to date show an increase in mucosal pathology as T4 cell counts decrease with progression of HIV disease. The most commonly observed mucosal pathologies were oral candidiasis and hairy leukoplakia. Destructive periodontal disease has occurred in about 25 percent of subjects examined. Longitudinal studies showed that about 30% of persons free from mucosal pathology at entry presented with pathology after six months of follow-up.

美国陆军人员和家属谁测试血清阳性 人类免疫缺陷病毒（HIV）的感染者 在沃尔特里德陆军医疗中心接受检查和治疗。 科目 也被邀请参加一项研究协议， 艾滋病毒感染的自然史，由沃尔特里德陆军进行 研究所。 口腔健康研究部分， NIDR是这项自然历史研究的一部分。 口腔部分记录了口腔疾病的患病率和发病率， 与HIV感染阶段相关的病理状况， 全身性疾病。 与这些疾病相关的风险因素是 也有特点，和口腔的作用表现为早期 研究疾病进展的预测因子或标志物。 领域 重点是粘膜病变，牙周状况，念珠菌感染， 感染和唾液成分。 迄今为止的结果显示， 在粘膜病理学中，T4细胞计数随着HIV的进展而减少 疾病 最常见的粘膜病变是口腔 念珠菌病和毛状白斑。 牙周病的危害有哪些 发生在大约25%的受试者身上。 纵向研究 表明，约30%的人在入境时没有粘膜病变， 在六个月的随访后出现病理学改变。