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MOLECULAR BIOLOGY OF PITUITARY GLYCOPROTEIN AND HYPOTHALAMIC RELEASING HORMONES

MOLECULAR BIOLOGY OF PITUITARY GLYCOPROTEIN AND HYPOTHALAMIC RELEASING HORMONES
垂体糖蛋白和下丘脑释放激素的分子生物学
批准号：
3776943
负责人：
B D WEINTRAUB
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3776943
关键词：
clone cells cyclic AMP gene expression gene induction /repression genetic regulation genetic regulatory element genetic transcription glycoproteins hormone regulation /control mechanism human genetic material tag hypothalamic hormones pituitary hormones protein kinase A protein kinase C protooncogene thyroid hormones thyrotropin thyrotropin releasing hormone

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中文摘要
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英文摘要
The human TSH beta gene is expressed only in the thyrotrophs of the anterior pituitary where it is regulated by hypothalamic hormones, cyclic AMP as well as thyroid hormone. Recent studies have indicated that TRH and cyclic AMP mediate their transcriptional action in large part through changes in phosphorylation of the specific pituitary factor pit-1 which binds to a region upstream of the start of transcription. In contrast, thyroid hormone mediates its inhibition through binding to a regulatory element downstream of the start of transcription in the first untranslated exon. We have recently characterized in detail a TGGGTCA motif at -1/+6 of the hTSH-beta gene that mediates, in conjunction with the upstream pit-1 site, protein kinase C and A as well as TRH stimulation of hTSH-beta gene expression. We have also shown that c-fos and c-jun which interact with this downstream site modulate T3 inhibition of hTSH-beta gene expression.
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