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BIOSYNTHESIS AND GLYCOSYLATION OF THYROTROPIN

BIOSYNTHESIS AND GLYCOSYLATION OF THYROTROPIN
促甲状腺素的生物合成和糖基化
批准号：
4690024
负责人：
B D WEINTRAUB
金额：
$0.0万
依托单位：
NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4690024
关键词：
antibiotics apolipoproteins carbohydrate biosynthesis carbohydrate structure hormone biosynthesis hormone regulation /control mechanism hormone related neoplasm /cancer pituitary neoplasms secretion thyroid hormones thyrotropin thyrotropin releasing hormone

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中文摘要
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英文摘要
Thyrotropin biosynthesis and carbohydrate processing has been studied under various physiologic conditions and in the presence of various inhibitors. Deoxynojirimycin, which inhibits glucosidase action and leads to accumulation of glucosylated precursors, caused inhibition of thyrotropin secretion. Thyroid hormone and thyrotropin-releasing hormone caused differential effects on thyrotropin apoprotein and carbohydrate synthesis and secretion. TSH carbohydrate structure is heterogeneous, and thyrotropin-releasing hormone caused a specific increase in synthesis and secretion of biantennary complex forms. Patients with invasive thyrotropin-secreting pituitary tumors may secrete TSH with aberrant carbohydrate structure.
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BIOSYNTHESIS AND GLYCOSYLATION OF THYROTROPIN
BIOSYNTHESIS AND GLYCOSYLATION OF THYROTROPIN
BIOSYNTHESIS, GLYCOSYLATION, AND ACTION OF THYROTROPIN--CLINICAL TRIALS OF TSH
MUTATIONS OF THE THYROID HORMONE RECEPTOR GENE IN THYROID HORMONE RESISTANCE
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