A combined genetic and small molecule approach to studying the role of the p38/MK2 stress signalling pathway in a human premature ageing syndrome

结合遗传和小分子方法研究 p38/MK2 应激信号通路在人类早衰综合征中的作用

• 批准号: ES/G037205/1
• 负责人: Mark Christopher Bagley
• 金额: $ 32.97万
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ES%2FG037205%2F1
• 关键词: combined; genetic; small; molecule; approach

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前，所有资助研究的摘要都不能在GTR中找到。这通常是因为在提交提案时并不需要摘要，但可能是因为它包含了个人详细信息等敏感信息。

项目成果

Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells.

• DOI: 10.3390/ph8020257
• 发表时间: 2015-06-03
• 期刊: Pharmaceuticals (Basel, Switzerland)
• 作者: Bagley MC;Baashen M;Chuckowree I;Dwyer JE;Kipling D;Davis T
• 通讯作者: Davis T

Regiocontrolled synthesis of 3- and 5-aminopyrazoles, pyrazolo[3,4-d]pyrimidines, pyrazolo[3,4-b]pyridines and pyrazolo[3,4-b]quinolinones as MAPK inhibitors

• DOI: 10.1016/j.tet.2013.07.055
• 发表时间: 2013-09-30
• 期刊: TETRAHEDRON
• 影响因子: 2.1
• 作者: Bagley, Mark C.;Baashen, Mohammed;Davis, Terence
• 通讯作者: Davis, Terence

Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors.

• DOI: 10.1186/1752-153x-5-83
• 发表时间: 2011-12-08
• 期刊: Chemistry Central journal
• 作者: Davis T;Dix MC;Rokicki MJ;Brook AJ;Widdowson CS;Kipling D;Bagley MC
• 通讯作者: Bagley MC

Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts.

• DOI: 10.3390/ph9020023
• 发表时间: 2016-04-28
• 期刊: Pharmaceuticals (Basel, Switzerland)
• 作者: Davis T;Brook AJ;Rokicki MJ;Bagley MC;Kipling D
• 通讯作者: Kipling D

Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome.

使用 p38 MAPK 抑制剂治疗维尔纳综合征。

• DOI: 10.3390/ph3061842
• 发表时间: 2010-06-04
• 期刊: Pharmaceuticals (Basel, Switzerland)
• 作者: Bagley MC;Davis T;Murziani PG;Widdowson CS;Kipling D
• 通讯作者: Kipling D