Approaches to the pathogenesis of psoriasis, an intractable human skin disorder

银屑病是一种难治性皮肤病，其发病机制尚不清楚。目前尚不清楚自身免疫是否参与银屑病的发病机制。由于corneodesmosin（CDSN）缺陷小鼠表现出类似于人类银屑病的皮肤表型，我们给受体小鼠移植CDSN缺陷皮肤的IL-22的中和抗体。注射抗IL-22中和抗体后，皮肤表型无明显变化。然而，我们还需要观察同时给予IL-23（一种Th 17炎性细胞因子）中和抗体是否会显示相同的结果，以便了解将来进一步确定银屑病的自身免疫特征。

Psoriasis is an intractable skin disorder whose pathogenesis is unknown. It is not clear whether autoimmunity is involved in the pathogenesis of psoriasis. Because corneodesmosin (CDSN)-deficient mice show the skin phenotypes resembling human psoriasis, we administered neutralizing antibody against IL-22 into the recipient mice grafted with CDSN-deficient skin. We found no obvious changes in the skin phenotypes by the injection of anti-IL-22 neutralizing antibody. We also need to see, however, whether the concomitant administration of neutralizing antibody against IL-23, a Th17 inflammatory cytokine, would show the same results in order to know to determine further the autoimmune features of psoriasis in the future.