Approaches to the pathogenesis of psoriasis, an intractable human skin disorder

牛皮癣是一种顽固性皮肤病，其发病机制尚不清楚。目前尚不清楚自身免疫是否参与牛皮癣的发病机制。由于角膜粘连蛋白（CDSN）缺陷小鼠的皮肤表型与人类牛皮癣相似，我们给移植了CDSN缺陷皮肤的受体小鼠注射了抗IL-22的中和抗体。我们发现注射抗il -22中和抗体后皮肤表型无明显变化。然而，为了进一步确定银屑病的自身免疫特征，我们还需要观察是否同时给予针对IL-23（一种Th17炎症细胞因子）的中和抗体会显示相同的结果。

Psoriasis is an intractable skin disorder whose pathogenesis is unknown. It is not clear whether autoimmunity is involved in the pathogenesis of psoriasis. Because corneodesmosin (CDSN)-deficient mice show the skin phenotypes resembling human psoriasis, we administered neutralizing antibody against IL-22 into the recipient mice grafted with CDSN-deficient skin. We found no obvious changes in the skin phenotypes by the injection of anti-IL-22 neutralizing antibody. We also need to see, however, whether the concomitant administration of neutralizing antibody against IL-23, a Th17 inflammatory cytokine, would show the same results in order to know to determine further the autoimmune features of psoriasis in the future.