HEMOSTATIC CHANGES ASSOCIATED WITH STRESS HORMONE INFUSION

与应激激素输注相关的止血变化

• 批准号: 3783619
• 负责人: BRIAN A ROSENFELD
• 金额: --
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3783619
• 关键词: blood chemistry; catecholamines; cortisol; glucagon; hemostatics; human subject; injury /disease stressor; intravenous administration; neuroendocrine system; surgery; trauma

The stress response is a systemic neural-humoral response to tissue injury. This can occur as a result of trauma or surgery to patients. The changes occurring with stress response include elevations in serum catecholamine, cortisol and glucagon levels. The infusion of these three hormones in normal volunteers has been shown to simulate many of the metabolic changes associated with surgery and injury. This project is designed to study these effects in normal volunteers when exposed to triple hormone stress infusion.

应激反应是对组织的全身性神经-体液反应 损伤这可能是患者创伤或手术的结果。的 伴随应激反应发生的变化包括血清 儿茶酚胺皮质醇和胰高血糖素水平。这三种药物的注入 正常志愿者体内的激素已经被证明可以模拟许多 与手术和损伤相关的代谢变化。这个项目是 旨在研究正常志愿者在暴露于 三重荷尔蒙压力注射