NEUROHORMONAL REGULATION OF SYSTEMATIC HEMOSTATIC FUNCTION
系统止血功能的神经激素调节
基本信息
- 批准号:6218266
- 负责人:
- 金额:$ 0.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-12-01 至 1999-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Unexplained acidosis occurs in up to 15% of patients following cardiac surgery, Since this disorder resolves spontaneously and cardiac output is similar in patients with and without lactic acidosis, it is likely this represents a type 2 lactic acidosis. Little is presently known regarding the mechanism responsible for this apparent Type 2 lactic acidosis. This study, which stems from a previous investigation on the neurohormonal regulation of systemic hemostatic function, is designed to evaluate the impact of stress hormones on acid-base balance and lactate concentrations. Volunteers in the original study on hemostatic function were noted to develop an apparent Type 2 lactic acidosis when randomized to the stress hormone infusion that contained epinephrine, cortisol, glucagon, angiotensin Ii, and vasopressin. Subsequently we have studied healthy volunteers receiving stress hormone infusion of all f hormones, four hormones (without angiotensin II), three hormones (without angiotensin or vasopressin) and during all of these infusions the volunteers have developed an apparent Type 2 lactic acidosis of the same magnitude. Presently we are studying healthy volunteers receiving epinephrine alone. The initial volunteer also has developed a type 2 lactic acidosis and given the cost of routinely evaluating postoperative lactic acidosis we are eager to evaluate subsequent volunteers.
心脏手术后高达15%的患者会发生原因不明的酸中毒,因为这种疾病会自动消失,而有和没有乳酸酸中毒的患者的心输出量相似,这很可能代表了2型乳酸酸中毒。关于这种明显的2型乳酸中毒的机制目前知之甚少。这项研究源于先前关于神经激素调节全身止血功能的研究,旨在评估应激激素对酸碱平衡和乳酸浓度的影响。在最初的止血功能研究中,志愿者在随机接受含有肾上腺素、皮质醇、胰升糖素、血管紧张素II和血管加压素的应激激素注射时,出现明显的2型乳酸血症。随后,我们研究了接受应激激素注射的健康志愿者,其中包括所有的f激素,四种激素(不含血管紧张素II),三种激素(不含血管紧张素或加压素),在所有这些注射过程中,志愿者都出现了相同程度的明显的2型乳酸酸中毒。目前,我们正在研究单独服用肾上腺素的健康志愿者。最初的志愿者也患上了II型乳酸酸中毒,考虑到常规评估术后乳酸酸中毒的费用,我们迫切希望评估后续的志愿者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BRIAN A ROSENFELD其他文献
BRIAN A ROSENFELD的其他文献
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{{ truncateString('BRIAN A ROSENFELD', 18)}}的其他基金
NEUROHORMONAL REGULATION OF SYSTEMATIC HEMOSTATIC FUNCTION
系统止血功能的神经激素调节
- 批准号:
6297541 - 财政年份:1998
- 资助金额:
$ 0.23万 - 项目类别:
NEUROHORMONAL REGULATION OF SYSTEMATIC HEMOSTATIC FUNCTION
系统止血功能的神经激素调节
- 批准号:
6114355 - 财政年份:1998
- 资助金额:
$ 0.23万 - 项目类别:
NEUROHORMONAL REGULATION OF SYSTEMATIC HEMOSTATIC FUNCTION
系统止血功能的神经激素调节
- 批准号:
6275590 - 财政年份:1997
- 资助金额:
$ 0.23万 - 项目类别:
ANESTHESIA/ANALGESIA EFFECTS ON PERIOPERATIVE HEMOSTASIS
麻醉/镇痛对围手术期止血的影响
- 批准号:
2519003 - 财政年份:1994
- 资助金额:
$ 0.23万 - 项目类别:
ANESTHESIA/ANALGESIA EFFECTS ON PERIOPERATIVE HEMOSTASIS
麻醉/镇痛对围手术期止血的影响
- 批准号:
2187836 - 财政年份:1994
- 资助金额:
$ 0.23万 - 项目类别:
ANESTHESIA/ANALGESIA EFFECTS ON PERIOPERATIVE HEMOSTASIS
麻醉/镇痛对围手术期止血的影响
- 批准号:
2187837 - 财政年份:1994
- 资助金额:
$ 0.23万 - 项目类别:
ANESTHESIA/ANALGESIA EFFECTS ON PERIOPERATIVE HEMOSTASIS
麻醉/镇痛对围手术期止血的影响
- 批准号:
2187834 - 财政年份:1994
- 资助金额:
$ 0.23万 - 项目类别:
ANESTHESIA/ANALGESIA EFFECTS ON PERIOPERATIVE HEMOSTASIS
麻醉/镇痛对围手术期止血的影响
- 批准号:
2770994 - 财政年份:1994
- 资助金额:
$ 0.23万 - 项目类别:
HEMOSTATIC CHANGES ASSOCIATED WITH STRESS HORMONE INFUSION
与应激激素输注相关的止血变化
- 批准号:
3783619 - 财政年份:
- 资助金额:
$ 0.23万 - 项目类别:
HEMOSTATIC CHANGES ASSOCIATED WITH STRESS HORMONE INFUSION
与应激激素输注相关的止血变化
- 批准号:
3847423 - 财政年份:
- 资助金额:
$ 0.23万 - 项目类别: