RISK OF HYPOGLYCEMIA WITH MORNING VS BEDTIME NPH INSULIN FOR TYPE II DIABETES

早晨与睡前 NPH 胰岛素治疗 II 型糖尿病的低血糖风险

• 批准号: 3786523
• 负责人: MATTHEW C RIDDLE
• 金额: --
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3786523
• 关键词: body physical activity; caloric dietary content; diabetes mellitus therapy; disease /disorder proneness /risk; drug administration rate /duration; fasting; functional ability; human subject; human therapy evaluation; hypoglycemia; insulin; noninsulin dependent diabetes mellitus

Using NPH insulin in the evening to control fasting hyperglycemia may address the pathophysiology of type II diabetes better than conventional morning dosage. This study tests the relative risk of hypoglycemia when patients are given equal doses of NPH insulin before breakfast or at bedtime under conditions of changing calorie intake and physical activity, simulating daily life.

晚上使用 NPH 胰岛素来控制空腹高血糖可能会 比传统方法更好地解决 II 型糖尿病的病理生理学问题 早晨剂量。 这项研究测试了低血糖的相对风险 患者在早餐前或早餐时给予等剂量的 NPH 胰岛素 改变卡路里摄入量和体力条件下的就寝时间 活动，模拟日常生活。