STEROID DIABETES--METABOLIC PATTERNS AND BASIS FOR TREATMENT

类固醇糖尿病——代谢模式和治疗基础

• 批准号: 3786526
• 负责人: MATTHEW C RIDDLE
• 金额: --
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3786526
• 关键词: carbohydrate metabolism; diabetes mellitus therapy; drug related diabetes mellitus; glucocorticoids; hormone regulation /control mechanism; human subject; noninsulin dependent diabetes mellitus

Steroid induced diabetes is more prevalent due to organ transplantation. Current practice is to treat persons with steroid diabetes like spontaneous Type II Diabetes, which we feel is incorrect. The time course of action of the glucocorticoid has not been considered in this formulation. We will test the hypothesis: Steroid diabetes had a metabolic fuel pattern distinct and separate from that of spontaneous Type II Diabetes Mellitus, related to the time course of action of glucocorticoids on carbohydrate metabolism.

由于器官移植，类固醇引起的糖尿病更为普遍。 目前的做法是治疗类固醇糖尿病的人， 自发性II型糖尿病，我们认为这是不正确的。 的时间 糖皮质激素的作用过程尚未考虑在此 公式化。 我们将检验这一假设：类固醇糖尿病 代谢燃料模式与自发的不同， II型糖尿病，与药物作用的时间过程相关 糖皮质激素对碳水化合物代谢的影响