TREATMENT AND PREVENTION OF BLISTERS IN DYSTROPIC EPIDERMOLYSIS BULLOSA

异位性大疱性表皮松解症中水泡的治疗和预防

• 批准号: 3785809
• 负责人: DAVID M. CARTER
• 金额: --
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3785809
• 关键词: antiinfective agents; autologous transplantation; blister; blood disorder; chemoprevention; disease /disorder prevention /control; epidermolysis bullosa; genetic mapping; human genetic material tag; human subject; human therapy evaluation; immunomodulators; immunotherapy; kidney disorder; malnutrition; medical complication; nutrition related tag; patient /disease registry; skin disorder chemotherapy; skin neoplasms; skin transplantation; skin ulcer; tissue /cell culture

Heterogeneous, heritable disorder of skin and mucous membranes, characterized by severe blistering after minor trauma. Profound morbidity but no proven therapy. Autografts of cultured epidermal cells. Antimicrobial and immunostimulatory treatments for ulcerated nonhealing blisters. National EB Registry. Studies: cutaneous malignancies, role of malnutrition in causing renal and hematologic dysfunction, delineation of multisystem defects characteristic of each form of EB pathology, gene mapping.

皮肤和粘膜的异质性遗传性疾病， 以轻微创伤后严重起泡为特征。 深刻 发病率，但没有经过验证的治疗方法。 培养的表皮细胞的自体移植。 溃疡不愈合的抗菌和免疫刺激治疗 水泡 国家EB登记处。 研究：皮肤恶性肿瘤，作用 营养不良引起肾功能和血液功能障碍， 每种形式的EB病理学特征的多系统缺陷，基因 映射.