Cytokine signalling and the regulation of normal and leukaemic blood cells

细胞因子信号传导以及正常和白血病血细胞的调节

• 批准号: nhmrc : 1078737
• 负责人: Prof Nic Nicola
• 金额: $ 63.26万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cytokine-signalling-regulation-blood-cells/518604
• 关键词: Cytokine; signalling; regulation; normal; leukaemic

The formation and actions of white blood cells are regulated by protein messengers called cytokines. Cytokines deliver their message by inducing the activation of signalling pathways that orchestrate the cell’s response to infection but when these responses occur too robustly or at inappropriate times they can lead to autoimmune disease, tissue damage and blood cancers. We study the naturally occurring feedback inhibitors of these processes in order to devise new treatments for these diseases.

白色血细胞的形成和活动受称为细胞因子的蛋白质信使调节。细胞因子通过诱导信号通路的激活来传递它们的信息，这些信号通路协调细胞对感染的反应，但是当这些反应发生得过于强烈或在不适当的时间发生时，它们可能导致自身免疫性疾病、组织损伤和血癌。我们研究这些过程的自然发生的反馈抑制剂，以设计这些疾病的新治疗方法。