Novel regulation of inflammasomes by cytokine signalling pathways in gastric disease

胃病中细胞因子信号通路对炎症小体的新调控

• 批准号: nhmrc : 1043491
• 负责人: A/Pr Richard Ferrero
• 金额: $ 44.99万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-regulation-inflammasomes-gastric-disease/111580
• 关键词: Novel; regulation; inflammasomes; cytokine; signalling

Stomach inflammation (gastritis) is strongly associated with Helicobacter pylori bacterial infection, and can also progress to gastric cancer. However, it remains largely unknown how Helicobacter triggers these gastric diseases in people. Using a mouse model which develops gastric inflammation and tumours, our aim is to determine the role of protein complexes in the stomach called inflammasomes in triggering chronic inflammatory responses to Helicobacter that lead to gastric disease.

胃炎(胃炎)与幽门螺杆菌感染密切相关，也可发展为胃癌。然而，在很大程度上仍不清楚幽门螺杆菌是如何在人体内引发这些胃病的。利用发展胃炎和肿瘤的小鼠模型，我们的目标是确定胃中称为炎症体的蛋白质复合体在触发对幽门螺杆菌的慢性炎症反应中所起的作用，从而导致胃病。