Cellular regulation of receptor signalling and cytokine responses

受体信号传导和细胞因子反应的细胞调节

• 批准号: nhmrc : 1098710
• 负责人: A/Pr Antje Blumenthal
• 金额: $ 59.12万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cellular-regulation-receptor-cytokine-responses/662392
• 关键词: Cellular; regulation; receptor; signalling; cytokine

Cell surface receptors and signalling pathways elicit the release of cytokines, or chemical messengers, to control inflammation, which is the body’s response to infection or danger. We have discovered a new signalling pathway that can turn off inflammation and help prevent inflammatory disease. Our studies will now define the molecular details of this pathway and show how new and existing drugs targeting this pathway can be optimally used to treat inflammation and cancer.

细胞表面受体和信号通路诱导细胞因子或化学信使的释放，以控制炎症，这是身体对感染或危险的反应。我们发现了一种新的信号通路，可以关闭炎症，帮助预防炎症性疾病。我们的研究现在将定义这一途径的分子细节，并展示针对这一途径的新药物和现有药物如何以最佳方式用于治疗炎症和癌症。