Identifying niche factors regulating distinct properties of AT2 stem cells
识别调节 AT2 干细胞独特特性的生态位因子
基本信息
- 批准号:9767857
- 负责人:
- 金额:$ 54.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-22 至 2022-05-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAblationAcuteAdult Respiratory Distress SyndromeAgingAlveolarAutomobile DrivingBindingBiochemistryBronchoscopyCell DeathCell ProliferationCell TransplantationCell TransplantsCell divisionCellsChronicChronic Obstructive Airway DiseaseCuesDataDiagnosisDiseaseDisease ProgressionEGF geneElderlyEnvironmentEpidermal Growth Factor ReceptorEpithelialEpithelial CellsFailureFibroblastsFosteringFunctional disorderGasesGoalsGrowthHumanImmuneInjuryIntegrinsKnowledgeLeadLearningLifeLigandsLongevityLungLung CapacityLung diseasesMaintenanceMapsMedicalMinorMitogensModelingMolecularMorbidity - disease rateMusNatural regenerationOrganParacrine CommunicationPathologyPatientsPharmacologyPneumoniaPopulationProductionProliferatingPropertyRNARegulationResearchResolutionRespiratory FailureRespiratory physiologyRoleSignal PathwaySignal TransductionSignaling MoleculeSiteSmokingStem cellsSurfaceTestingTherapeuticTimeTissuesTransplantationWNT Signaling PathwayWorkalveolar type II cellautocrinebasecell behaviorcell injurydimeridiopathic pulmonary fibrosisimprovedin vivoinjuredlung injurylung regenerationmortalitynew technologynovelparacrinepreventprogramsreceptorreconstitutionrepairedresilienceresponseresponse to injurysingle cell analysissingle cell technologystem cell biologytherapeutic development
项目摘要
PROJECT SUMMARY
A number of serious respiratory diseases cause problems with gas exchange, which is the principal function of
the lungs. Some of these are sudden in onset, like lung injury from a severe pneumonia, while others develop
over long periods of time, like COPD and Idiopathic Pulmonary Fibrosis (IPF). There is some evidence that the
chronic forms of respiratory failure result from loss of the capacity of the lungs to maintain themselves, in part
due to dysfunction of resident lung stem cells that normally perform this role. Therefore, discovering the
specific molecular and cellular mechanisms by which lung stem cells are regulated throughout life may be
helpful for understanding how COPD and IPF develop. Achieving this deep level of understanding about lung
stem cell regulation may lead to improved strategies to predict, diagnose, and even pharmacologically treat
such diseases. Furthermore, given the easy accessibility of the lung via medical bronchoscopy, it is an ideal
organ to target with the delivery of healthy stem cells that might prevent disease progression or even produce
improvement if they can be successfully transplanted into diseased lungs. We have found that one of the
functional cells in the gas exchange region, the alveolar type II (AT2) cell, acts as a stem cell for mouse lung
throughout the lifespan, and identified several factors that regulate its activity. The AIMS of this proposal are to
expand our understanding of how these stem cells are regulated by studying the local environment that
provides the signals that control their activity, including proliferation and differentiation. We will investigate
three specific and distinct aspects of the stem cell behavior, including how it is induced to proliferate to
generate new cells, how it attains the capacity to transiently regulate itself in response to injury, and whether
the regulatory environment is as or more important than the stem cell itself for maintaining the lungs over the
lifespan. Our findings will significantly deepen our understanding of precisely how these lung stem cells can be
deliberately manipulated to generate large numbers suitable for cell transplantation, or by pharmacologically
driving their activity for therapeutic 're-growth' purposes.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Tushar Jasubhai DESAI其他文献
Tushar Jasubhai DESAI的其他文献
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{{ truncateString('Tushar Jasubhai DESAI', 18)}}的其他基金
Cellular and molecular mechanisms of alveolar repair
肺泡修复的细胞和分子机制
- 批准号:
10750085 - 财政年份:2023
- 资助金额:
$ 54.39万 - 项目类别:
Identifying niche factors regulating distinct properties of AT2 stem cells
识别调节 AT2 干细胞独特特性的生态位因子
- 批准号:
9576667 - 财政年份:2018
- 资助金额:
$ 54.39万 - 项目类别:
Identifying niche factors regulating distinct properties of AT2 stem cells
识别调节 AT2 干细胞独特特性的生态位因子
- 批准号:
10178079 - 财政年份:2018
- 资助金额:
$ 54.39万 - 项目类别:
Single Cell Profiling and In Vivo Cellular Interrogation of Alveolar Stem Cells
肺泡干细胞的单细胞分析和体内细胞分析
- 批准号:
9130386 - 财政年份:2015
- 资助金额:
$ 54.39万 - 项目类别:
Development and maintenance of the alveolar type 1 cell
肺泡 1 型细胞的发育和维持
- 批准号:
7386391 - 财政年份:2008
- 资助金额:
$ 54.39万 - 项目类别:
Development and maintenance of the alveolar type 1 cell
肺泡 1 型细胞的发育和维持
- 批准号:
7552017 - 财政年份:2008
- 资助金额:
$ 54.39万 - 项目类别:
Development and maintenance of the alveolar type 1 cell
肺泡 1 型细胞的发育和维持
- 批准号:
7754452 - 财政年份:2008
- 资助金额:
$ 54.39万 - 项目类别:
Development and maintenance of the alveolar type 1 cell
肺泡 1 型细胞的发育和维持
- 批准号:
8207255 - 财政年份:2008
- 资助金额:
$ 54.39万 - 项目类别:
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