A COMPARISON OF STRAINS OF E. COLI TO PRODUCE SEPTIC SHOCK IN DOGS

引起狗败血性休克的大肠杆菌菌株比较

• 批准号: 3853021
• 负责人: C NATANSON
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3853021
• 关键词: Escherichia coli; animal morbidity; animal mortality; bacterial toxins; dogs; endotoxins; genetic strain; hemodynamics; shock; virulence

While live bacteria commonly cause infection, the relative role of bacterial toxins versus live bacteria to produce morbidity and mortality is not known. If bacterial toxins are important factors, therapies directed at these toxins may be required. Even if no bacteria remain alive or grow, these preformed toxins may be important in determining morbidity and mortality. Therapies directed at these toxins may be important additions to antibiotic therapy. Using two E. coli in the canine model, we designed a study in the summer of 1988 to determine whether organism virulence factors or bacterial toxins were more important in producing septic shock. Measures of hemodynamic shock, blood cultures, endotoxin levels and survival were done serially with both organisms live, both organisms killed, and with purified endotoxin from these organisms. Approximately 4 man years have gone into this study. Preliminary results from this study have been presented at the American Federation of Clinical Research and the Society of Critical Care Medicine. This presentation won a poster award in 1990. There has been much interest in these data as determination of the factors that produce morbidity in infection will guide trials for future therapies of children and adults with septic shock.

虽然活细菌通常会引起感染， 细菌毒素与活细菌产生的发病率和死亡率， 不知道。 如果细菌毒素是重要因素， 可能需要这些毒素。 即使没有细菌存活或生长， 这些预先形成的毒素在确定发病率方面可能是重要的， mortality.针对这些毒素的治疗可能是对 抗生素治疗 使用两个E。我们在2005年夏天设计了一项研究， 1988年确定是否有生物体毒力因子或细菌毒素 更容易导致感染性休克 血流动力学指标 休克、血培养、内毒素水平和存活率连续进行 两种生物都活了，两种生物都死了， 这些生物的内毒素。 大约4个人年的时间已经进入了 本研究 这项研究的初步结果已在 美国临床研究联合会和重症监护学会 药 这张海报在1990年获得了海报奖。 出现 许多人对这些数据很感兴趣， 感染发病率将指导未来儿童治疗试验 和感染性休克的成年人。