CANINE MODEL OF SEPTIC SHOCK

建立了一种感染性休克的犬模型， 和治疗这一常见问题。 1)致病微生物剂量的影响-一系列相同的微生物 对狗给予剂量以评估血液动力学的影响 有机体的质量。 2)病原微生物的鉴定-各种微生物的相同数量 包括革兰氏阳性菌和革兰氏阴性菌在内的微生物 以确定不同的生物是否有不同的影响。 3)治疗效果-感染后，容量的影响， 升压药和各种抗生素对脓毒症结局的影响 评估。 这些研究是了解感染如何导致 危及生命的血压下降，什么治疗可以是 以更有效地治疗此类感染。

A dog model of septic shock has been developed to study the pathophysiology and therapy of this common problem. 1) Effect of dose of causative organism - Identical organisms in a range of doses are being administered to dogs to assess influence of hemodynamics of the quality of organisms. 2) Identify of causative organism - Identical quantities of a variety of organisms including gram-positive and gram-negative are being administered to dogs to determine if different organisms have different effects. 3) Effect of therapy - Following infection, the effects of volume, pressors, and various antibiotics on the outcome of sepsis are being assessed. These studies are an important effort to understand how infection causes life-threatening drops in blood pressure and what therapies can be developed to treat such infections more effectively.