CELLULAR AND MOLECULAR STUDIES OF AUTOIMMUNE DISEASE

这四个联动合作的总目标 项目研究的是细胞和分子基础。 实验性和人类自身免疫性疾病。 血清学、细胞学、生化和分子生物学技术 将被用来分析编码基因及其产物 自身抗体II类抗原和临界抗体的特异性 在细胞协作中起重要作用的分子 如Fc受体。此外，细胞之间的合作 抗原提呈细胞和淋巴细胞的主要亚群 介导体液或细胞自身免疫反应的将是 通过细胞、生物化学和分子生物学进行研究 接近了。每个单独的项目都有一个主要目标来提供 对自身免疫性疾病发病机制的重要见解。

The overall goal of these four interlocking and cooperative projects is to study the cellular and molecular basis of experimental and human autoimmune disease. Serologic, cellular, biochemical and molecular biology techniques will be used to analyze the genes and their product encoding the specificity of autoantibodies class II antigens as well as of critical molecules which play an important role in the cell cooperation such as the Fc receptor. Furthermore, cell cooperation between antigens presenting cells and major subpopulations of lymphocytes mediating either humoral or cellular autoimmune response will be studied by cellular, biochemcial and molecular biology approaches. Each individual project has a major aim to provide important insights in the pathogenesis of autoimmune disease.