课题基金 / 基金详情

ROLE OF ENDOGENOUS AND RECOMBINANT RETROVIRUSES IN LEUKEMIA AND DIFFERENTIATION

ROLE OF ENDOGENOUS AND RECOMBINANT RETROVIRUSES IN LEUKEMIA AND DIFFERENTIATION
内源性和重组逆转录病毒在白血病和分化中的作用
批准号：
3818158
负责人：
B W CHESEBRO
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3818158
关键词：
Friend leukemia Friend virus cellular oncology gene expression genetic recombination genetic strain hemolytic anemia laboratory mouse molecular cloning molecular oncology newborn animals point mutation protein engineering protein sequence splenomegaly viral leukemia viral leukemogenesis virus envelope virus genetics virus infection mechanism

项目摘要

项目成果

B W CHESEBRO的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The goal of this work is to study mechanisms of pathogenesis of murine retroviruses. Previous studies showed that two closely related variants of Friend murine leukemia viruses differed in their ability to induce hemolytic anemia and splenomegaly shortly after inoculation into newborn mice. In vitro construction of recombinants between these strains demonstrated that this difference was due to differences in the viral envelope gene. DNA sequencing has revealed only 2 sequence differences between these strains, and site-specific mutagenesis has now identified a single amino acid responsible for this alteration in pathogenesis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ROLE OF ENDOGENOUS AND RECOMBINANT RETROVIRUSES IN LEUKEMIA AND DIFFERENTIATION
GENETICALLY CONTROLLED MECHANISMS OF RECOVERY FROM FRIEND VIRUS-INDUCED LEUKEMIA
ROLE OF ENDOGENOUS AND RECOMBINANT RETROVIRUSES IN LEUKEMIA AND DIFFERENTIATION
MECHANISMS OF PATHOGENESIS AND RECOVERY IN FRIEND RETROVIRUS-INDUCED LEUKEMIA
海外基金