DECIPHERING THE ROLE OF FOXP1 IN MAMMARY STEM CELLS AND DEVELOPMENT

破译 FOXP1 在乳腺干细胞和发育中的作用

• 批准号: nhmrc : 1144793
• 负责人: Prof Jane Visvader
• 金额: $ 38.48万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deciphering-role-foxp1-cells-development/1320274
• 关键词: DECIPHERING; ROLE; FOXP1; MAMMARY; STEM

Breast (mammary) epithelial cells undergo major changes across developmental stages, including puberty, pregnancy and lactation. This project will focus on the role of the molecular regulator, Foxp1, and how it influences normal mammary maturation. This work will inform whether Foxp1 is critical for controlling the activation of dormant stem cells and if this pathway can contribute to breast cancer formation when disrupted.

乳腺上皮细胞在发育阶段经历重大变化，包括青春期、妊娠期和哺乳期。该项目将重点关注分子调节因子Foxp1的作用，以及它如何影响正常的乳腺成熟。这项工作将告知Foxp 1是否对于控制休眠干细胞的激活至关重要，以及该途径被破坏时是否会导致乳腺癌的形成。