Determination of the cellular origins of breast cancer

乳腺癌细胞起源的确定

• 批准号: nhmrc : 1085191
• 负责人: Prof Jane Visvader
• 金额: $ 47.05万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determination-cellular-origins-breast-cancer/519067
• 关键词: Determination; cellular; origins; breast; cancer

Breast cancer is a highly heterogeneous disease with multiple molecular and histological subtypes. We propose to use novel genetically engineered mice to understand breast inter-tumoral heterogeneity by dissecting the cells of origin of breast cancer in vivo. Initially, we will examine whether long-lived stem or progenitor cells are the targets of breast carcinogenesis induced by a progesterone derivative using our state-of-the-art multi-coloured reporter models to track the cells in vivo.

乳腺癌是一种高度异质性的疾病，具有多种分子和组织学亚型。我们建议使用新的基因工程小鼠，通过解剖乳腺癌的起源细胞来了解乳腺肿瘤间的异质性。最初，我们将研究是否长寿的干细胞或祖细胞是由孕激素衍生物诱导的乳腺癌发生的目标，使用我们最先进的多色报告模型来跟踪体内的细胞。