Deciphering breast cancer heterogeneity to improve breast cancer outcomes

解读乳腺癌异质性以改善乳腺癌结果

• 批准号: nhmrc : 1102742
• 负责人: Prof Jane Visvader
• 金额: $ 52.98万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deciphering-breast-cancer-cancer-outcomes/662630
• 关键词: Deciphering; breast; cancer; heterogeneity; improve

Breast cancer is a very heterogeneous disease. Patients are often treated in a ‘one size fits all’ approach, but response to therapy remains quite disparate. To better personalise therapy, there is a pressing need to define the precise cell types and initiating genetic events that give rise to breast cancer. This application is focussed on understanding the molecular and cellular origins of breast cancer, with the potential of identifying new prognostic markers and therapeutic targets.

乳腺癌是一种异质性非常强的疾病。患者通常采用“一刀切”的方法进行治疗，但对治疗的反应仍然截然不同。为了更好地进行个性化治疗，迫切需要定义精确的细胞类型和引发乳腺癌的遗传事件。该应用的重点是了解乳腺癌的分子和细胞起源，并有可能确定新的预后标志物和治疗靶点。