Biological role and partners of the LIM domain protein LMO4 in breast epithelium

LIM结构域蛋白LMO4在乳腺上皮中的生物学作用和伙伴

• 批准号: nhmrc : 126400
• 负责人: Prof Jane Visvader
• 金额: $ 8.01万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biological-role-partners-breast-epithelium/82369
• 关键词: Biological; role; partners; LIM; domain

Breast cancer is the most common cancer affecting women, with 1 in 14 developing this disease. Although treatment of breast cancer has substantially improved over the last few years, 30% of women diagnosed with this cancer will die from it. One major focus of cancer research is the identification of genes involved in tumour development and definition of their precise role in cancer cells. The design of effective therapeutic inhibitors of cancer requires an understanding of the basic molecular and cellular biology behind the genetic changes thought to contribute to cancer. The focus of our research is to understand normal cellular mechanisms that drive growth and differentiation of breast tissue, and those changes that lead to breast cancer. Nuclear regulatory proteins have been implicated in many different types of cancers and leukaemias. We aim to identify the key regulators in breast tissue, characterising both their structural properties and biological roles, with the ultimate view of understanding how they divert a normal cell to a cancerous cell.

乳腺癌是影响女性的最常见癌症，每14人中就有1人患有这种疾病。虽然乳腺癌的治疗在过去几年中有了很大的改善，但30%的女性被诊断患有这种癌症会死于它。癌症研究的一个主要焦点是识别与肿瘤发展有关的基因，并确定它们在癌细胞中的确切作用。设计有效的癌症治疗抑制剂需要理解被认为有助于癌症的遗传变化背后的基本分子和细胞生物学。我们研究的重点是了解驱动乳腺组织生长和分化的正常细胞机制，以及导致乳腺癌的变化。核调节蛋白与许多不同类型的癌症和白血病有关。我们的目标是确定乳腺组织中的关键调节因子，描述它们的结构特性和生物学作用，最终了解它们如何将正常细胞转移到癌细胞。